Annotations: 2YB8

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2yb8b_	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	WD40-repeat	automated matches	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	WD40 repeat-like	8053352	3001694	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00400,PF12265	e2yb8B1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400,PF12265	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF12265	Histone-binding protein RBBP4 or subunit C of CAF1 complex (CAF1C_H4-bd)	Histone-binding protein RBBP4 or subunit C of CAF1 complex	-	Repeat
B	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	POLYCOMB PROTEIN SU(Z)12	DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding chromatin binding chromatin DNA binding cation binding ion binding metal ion binding small molecule binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process developmental process neurogenesis multicellular organism development multicellular organismal process cellular developmental process cell differentiation anatomical structure development nervous system development system development protein-DNA complex organization cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression negative regulation of gene expression facultative heterochromatin formation negative regulation of gene expression, epigenetic response to stimulus negative regulation of response to stimulus negative regulation of response to gamma radiation response to ionizing radiation regulation of response to stimulus regulation of response to gamma radiation response to radiation response to abiotic stimulus response to gamma radiation	RSC-type complex membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure catalytic complex protein-DNA complex nucleus nuclear protein-containing complex chromatin chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle RSC-type complex membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure catalytic complex protein-DNA complex nucleus nuclear protein-containing complex chromatin chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle SWI/SNF superfamily-type complex non-membrane-bounded organelle histone methyltransferase complex membrane-enclosed lumen transferase complex intracellular organelle lumen nucleoplasm organelle lumen methyltransferase complex nuclear lumen PcG protein complex ESC/E(Z) complex
B	PROBABLE HISTONE-BINDING PROTEIN CAF1	protein binding binding histone binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding histone deacetylase binding enzyme binding identical protein binding protein binding binding histone binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding histone deacetylase binding enzyme binding identical protein binding protein homodimerization activity protein dimerization activity	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process developmental process multicellular organism development multicellular organismal process segmentation anatomical structure development pattern specification process regionalization segment specification regulation of mitotic cell cycle cell cycle regulation of cell cycle mitotic cell cycle eggshell chorion gene amplification cellular component assembly involved in morphogenesis reproductive process cellular process involved in reproduction in multicellular organism developmental process involved in reproduction cellular component organization cellular component biogenesis cellular anatomical entity morphogenesis cellular component assembly cellular component organization or biogenesis DNA amplification multicellular organismal reproductive process DNA metabolic process egg chorion assembly anatomical structure morphogenesis anatomical structure formation involved in morphogenesis DNA biosynthetic process external encapsulating structure organization protein-DNA complex organization chromatin organization chromatin remodeling heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression negative regulation of gene expression facultative heterochromatin formation negative regulation of gene expression, epigenetic DNA replication-dependent chromatin assembly positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process nucleosome organization transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle polytene chromosome chromosome cellular anatomical entity non-membrane-bounded organelle protein-containing complex CAF-1 complex membrane-bounded organelle histone methyltransferase complex catalytic complex nucleus intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle polytene chromosome chromosome cellular anatomical entity non-membrane-bounded organelle protein-containing complex CAF-1 complex membrane-bounded organelle histone methyltransferase complex catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex intracellular organelle lumen nucleoplasm organelle lumen methyltransferase complex nuclear lumen Sin3-type complex nuclear chromosome histone deacetylase complex protein-DNA complex chromatin transcription regulator complex PcG protein complex ESC/E(Z) complex Myb complex ATPase complex NuRD complex SWI/SNF superfamily-type complex CHD-type complex NURF complex ISWI-type complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR019135	Polycomb protein, VEFS-Box	Domain
B	IPR019775	WD40 repeat, conserved site	Conserved Site
B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B	IPR022052	Histone-binding protein RBBP4, N-terminal	Domain
B	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
B	IPR001680	WD40 repeat	Repeat
B	IPR020472	G-protein beta WD-40 repeat	Repeat

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.