2Y6T

Molecular Recognition of Chymotrypsin by the Serine Protease Inhibitor Ecotin from Yersinia pestis

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2y6ta_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	(alpha,gamma)-chymotrypsin(ogen)	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d2y6tb_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	(alpha,gamma)-chymotrypsin(ogen)	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d2y6tc_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	(alpha,gamma)-chymotrypsin(ogen)	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D	d2y6td_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	(alpha,gamma)-chymotrypsin(ogen)	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
E	d2y6te_	All beta proteins	Ecotin, trypsin inhibitor	Ecotin, trypsin inhibitor	Ecotin, trypsin inhibitor	automated matches	(Yersinia pseudotuberculosis YPIII ) [TaxId: 502800 ],	SCOPe (2.08)
F	d2y6tf_	All beta proteins	Ecotin, trypsin inhibitor	Ecotin, trypsin inhibitor	Ecotin, trypsin inhibitor	automated matches	(Yersinia pseudotuberculosis YPIII ) [TaxId: 502800 ],	SCOPe (2.08)
G	d2y6tg_	All beta proteins	Ecotin, trypsin inhibitor	Ecotin, trypsin inhibitor	Ecotin, trypsin inhibitor	automated matches	(Yersinia pseudotuberculosis YPIII ) [TaxId: 502800 ],	SCOPe (2.08)
H	d2y6th_	All beta proteins	Ecotin, trypsin inhibitor	Ecotin, trypsin inhibitor	Ecotin, trypsin inhibitor	automated matches	(Yersinia pseudotuberculosis YPIII ) [TaxId: 502800 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Trypsin-like serine proteases	8042128	3000114	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Trypsin-like serine proteases	8042128	3000114	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Trypsin-like serine proteases	8042128	3000114	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Trypsin-like serine proteases	8042128	3000114	SCOP2B (2022-06-29)
E	SCOP2 Family	Ecotin trypsin inhibitor	8078949	4002448	SCOP2 (2022-06-29)
E	SCOP2 Superfamily	Ecotin trypsin inhibitor	8078950	3001256	SCOP2 (2022-06-29)
F	SCOP2B Superfamily	Ecotin trypsin inhibitor	8078950	3001256	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Ecotin trypsin inhibitor	8078950	3001256	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Ecotin trypsin inhibitor	8078950	3001256	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00089	e2y6tA2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
B	PF00089	e2y6tB2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
C	PF00089	e2y6tC2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
D	PF00089	e2y6tD2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
E	PF03974	e2y6tE1	A: beta sandwiches	X: Ecotin, trypsin inhibitor (From Topology)	H: Ecotin, trypsin inhibitor (From Topology)	T: Ecotin, trypsin inhibitor	F: PF03974	ECOD (1.6)
F	PF03974	e2y6tF1	A: beta sandwiches	X: Ecotin, trypsin inhibitor (From Topology)	H: Ecotin, trypsin inhibitor (From Topology)	T: Ecotin, trypsin inhibitor	F: PF03974	ECOD (1.6)
G	PF03974	e2y6tG1	A: beta sandwiches	X: Ecotin, trypsin inhibitor (From Topology)	H: Ecotin, trypsin inhibitor (From Topology)	T: Ecotin, trypsin inhibitor	F: PF03974	ECOD (1.6)
H	PF03974	e2y6tH1	A: beta sandwiches	X: Ecotin, trypsin inhibitor (From Topology)	H: Ecotin, trypsin inhibitor (From Topology)	T: Ecotin, trypsin inhibitor	F: PF03974	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
B	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
C	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
D	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
E	2.60.40.550	Mainly Beta	Sandwich	Immunoglobulin-like	Ecotin	CATH (4.3.0)
F	2.60.40.550	Mainly Beta	Sandwich	Immunoglobulin-like	Ecotin	CATH (4.3.0)
G	2.60.40.550	Mainly Beta	Sandwich	Immunoglobulin-like	Ecotin	CATH (4.3.0)
H	2.60.40.550	Mainly Beta	Sandwich	Immunoglobulin-like	Ecotin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain
E, F, G, H	PF03974	Ecotin (Ecotin)	Ecotin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	CHYMOTRYPSINOGEN A	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity protein binding binding serpin family protein binding	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process multicellular organismal process digestion	protein-containing complex serine protease inhibitor complex protease inhibitor complex peptidase inhibitor complex extracellular region cellular anatomical entity
E, F, G, H	ECOTIN	enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity	-	periplasmic space cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR001254	Serine proteases, trypsin domain	Domain
A, B, C, D	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A, B, C, D	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A, B, C, D	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
A, B, C, D	IPR001314	Peptidase S1A, chymotrypsin family	Family
A, B, C, D	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
E, F, G, H	IPR005658	Proteinase inhibitor I11, ecotin	Family
E, F, G, H	IPR036198	Ecotin superfamily	Homologous Superfamily
E, F, G, H	IPR023084	Proteinase inhibitor I11, ecotin, gammaproteobacteria	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.