2XXL

Crystal structure of drosophila Grass clip serine protease of Toll pathway

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Clip domain	8047133	4005461	SCOP2 (2022-06-29)
A	SCOP2 Family	Eukaryotic proteases	8104053	4000286	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Clip domain	8104050	3002812	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Trypsin-like serine proteases	8104054	3000114	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Clip domain	8104050	3002812	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Trypsin-like serine proteases	8104054	3000114	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00089	e2xxlA2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
A	PF12032	e2xxlA1	A: few secondary structure elements	X: CLIP domain (From Topology)	H: CLIP domain (From Topology)	T: CLIP domain	F: PF12032	ECOD (1.6)
B	PF00089	e2xxlB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
B	PF12032	e2xxlB2	A: few secondary structure elements	X: CLIP domain (From Topology)	H: CLIP domain (From Topology)	T: CLIP domain	F: PF12032	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1640.30	Alpha Beta	2-Layer Sandwich	mini-chromosome maintenance (MCM) complex, chain A, domain 1		CATH (4.3.0)
A	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
B	3.30.1640.30	Alpha Beta	2-Layer Sandwich	mini-chromosome maintenance (MCM) complex, chain A, domain 1		CATH (4.3.0)
B	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF12032	Regulatory CLIP domain of proteinases (CLIP)	Regulatory CLIP domain of proteinases	CLIP is a regulatory domain which controls the proteinase action of various proteins of the trypsin family, e.g. easter and pap2. The CLIP domain remains linked to the protease domain after cleavage of a conserved residue which retains the protein in ...	CLIP is a regulatory domain which controls the proteinase action of various proteins of the trypsin family, e.g. easter and pap2. The CLIP domain remains linked to the protease domain after cleavage of a conserved residue which retains the protein in zymogen form. It is named CLIP because it can be drawn in the shape of a paper clip. It has many disulphide bonds and highly conserved cysteine residues, and so it folds extensively. [1] [2]	Domain
A, B	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	GRAM-POSITIVE SPECIFIC SERINE PROTEASE, ISOFORM B	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding serine hydrolase activity hydrolase activity catalytic activity peptidase activity catalytic activity, acting on a protein serine-type peptidase activity serine-type endopeptidase activity endopeptidase activity	regulation of humoral immune response regulation of immune effector process positive regulation of response to biotic stimulus regulation of cellular process response to stimulus antifungal peptide production positive regulation of macromolecule biosynthetic process response to biotic stimulus positive regulation of metabolic process antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of immune response antifungal humoral response organic substance biosynthetic process regulation of immune system process regulation of humoral immune response regulation of immune effector process positive regulation of response to biotic stimulus regulation of cellular process response to stimulus antifungal peptide production positive regulation of macromolecule biosynthetic process response to biotic stimulus positive regulation of metabolic process antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of immune response antifungal humoral response organic substance biosynthetic process regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of immune system process regulation of biological process response to other organism immune response cellular metabolic process response to external stimulus regulation of cellular metabolic process positive regulation of antifungal peptide production immune effector process regulation of gene expression regulation of defense response to fungus biosynthetic process regulation of response to stimulus defense response to other organism positive regulation of defense response positive regulation of production of molecular mediator of immune response regulation of immune response metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response regulation of metabolic process regulation of defense response humoral immune response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process antimicrobial humoral response positive regulation of response to stimulus positive regulation of antimicrobial peptide production positive regulation of humoral immune response organic substance metabolic process positive regulation of response to external stimulus positive regulation of biosynthetic process antimicrobial peptide production response to stress regulation of response to stress positive regulation of immune effector process response to external biotic stimulus positive regulation of cellular process production of molecular mediator of immune response regulation of biosynthetic process regulation of antimicrobial humoral response defense response biological regulation defense response to symbiont regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of antifungal peptide production regulation of cellular biosynthetic process defense response to fungus positive regulation of antimicrobial humoral response regulation of antimicrobial peptide production positive regulation of gene expression immune system process cellular process response to fungus positive regulation of cellular biosynthetic process antibacterial peptide production positive regulation of antimicrobial peptide biosynthetic process response to bacterium positive regulation of antibacterial peptide biosynthetic process regulation of antimicrobial peptide biosynthetic process peptide biosynthetic process antibacterial peptide biosynthetic process peptide metabolic process regulation of antibacterial peptide production defense response to bacterium positive regulation of defense response to bacterium regulation of defense response to bacterium antibacterial humoral response positive regulation of antibacterial peptide production antimicrobial peptide biosynthetic process regulation of antibacterial peptide biosynthetic process innate immune response Toll receptor ligand protein activation cascade protein activation cascade organonitrogen compound metabolic process primary metabolic process protein maturation protein metabolic process proteolysis defense response to Gram-positive bacterium	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A, B	IPR022700	Proteinase, regulatory CLIP domain	Domain
A, B	IPR001314	Peptidase S1A, chymotrypsin family	Family
A, B	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A, B	IPR001254	Serine proteases, trypsin domain	Domain
A, B	IPR038565	Proteinase, regulatory CLIP domain superfamily	Homologous Superfamily
A, B	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A, B	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.