2XQ2

Structure of the K294A mutant of vSGLT

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SNF-like	8092933	3001654	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SNF-like	8092933	3001654	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00474,PF01102	e2xq2A1	A: alpha complex topology	X: Sodium:neurotransmitter symporter family (SNF)-like (From Topology)	H: Sodium:neurotransmitter symporter family (SNF)-like (From Topology)	T: Sodium:neurotransmitter symporter family (SNF)-like	F: PF00474,PF01102	ECOD (1.6)
B	PF00474	e2xq2B1	A: alpha complex topology	X: Sodium:neurotransmitter symporter family (SNF)-like (From Topology)	H: Sodium:neurotransmitter symporter family (SNF)-like (From Topology)	T: Sodium:neurotransmitter symporter family (SNF)-like	F: PF00474	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1730.10	Mainly Alpha	Up-down Bundle	Sodium/glucose cotransporter	Sodium/glucose cotransporter	CATH (4.3.0)
B	1.20.1730.10	Mainly Alpha	Up-down Bundle	Sodium/glucose cotransporter	Sodium/glucose cotransporter	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00474	Sodium:solute symporter family (SSF)	Sodium:solute symporter family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SODIUM/GLUCOSE COTRANSPORTER	active transmembrane transporter activity transporter activity symporter activity transmembrane transporter activity secondary active transmembrane transporter activity	localization transport organic substance transport carbohydrate transport establishment of localization monoatomic ion transport monoatomic cation transport sodium ion transport metal ion transport	cell periphery plasma membrane membrane cellular anatomical entity
B	SODIUM/GLUCOSE COTRANSPORTER	active transmembrane transporter activity transporter activity symporter activity transmembrane transporter activity secondary active transmembrane transporter activity	localization transport organic substance transport carbohydrate transport establishment of localization monoatomic ion transport monoatomic cation transport sodium ion transport metal ion transport	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018212	Sodium/solute symporter, conserved site	Conserved Site
A	IPR001734	Sodium/solute symporter	Family
A	IPR038377	Sodium/glucose symporter superfamily	Homologous Superfamily
B	IPR018212	Sodium/solute symporter, conserved site	Conserved Site
B	IPR001734	Sodium/solute symporter	Family
B	IPR038377	Sodium/glucose symporter superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	APC (Amino acid-Polyamine-organoCation) superfamily	Solute:sodium symporter

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Solute Sodium Symporter (SSS) Family	SGLT Sodium Galactose Transporter, K294A mutant

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.