Annotations: 2XPI

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	CDC26-like	8053844	3002235	SCOP2B (2022-06-29)
D [auth E]	SCOP2 Family	ANAPC_CDC26-like	8044944	4004216	SCOP2 (2022-06-29)
D [auth E]	SCOP2 Superfamily	CDC26-like	8053844	3002235	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00515	e2xpiA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00515	ECOD (1.6)
A	PF12895	e2xpiA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12895	ECOD (1.6)
C [auth D]	PF00515	e2xpiD2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00515	ECOD (1.6)
C [auth D]	PF12895	e2xpiD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12895	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
C [auth D]	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth D]	PF12895	Anaphase-promoting complex, cyclosome, subunit 3 (ANAPC3)	Anaphase-promoting complex, cyclosome, subunit 3	-	Repeat
B, D [auth E]	PF10471	Anaphase-promoting complex APC subunit CDC26 (ANAPC_CDC26)	Anaphase-promoting complex APC subunit CDC26	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth D]	ANAPHASE-PROMOTING COMPLEX SUBUNIT CUT9	-	regulation of chromosome segregation regulation of cellular process regulation of mitotic sister chromatid separation positive regulation of biological process mitotic cell cycle cellular component organization mitotic sister chromatid segregation positive regulation of cell cycle process cell cycle mitotic sister chromatid separation cellular component organization or biogenesis regulation of cell cycle chromosome segregation positive regulation of cellular process regulation of chromosome segregation regulation of cellular process regulation of mitotic sister chromatid separation positive regulation of biological process mitotic cell cycle cellular component organization mitotic sister chromatid segregation positive regulation of cell cycle process cell cycle mitotic sister chromatid separation cellular component organization or biogenesis regulation of cell cycle chromosome segregation positive regulation of cellular process cell cycle process regulation of biological process mitotic nuclear division regulation of cell cycle process organelle fission biological regulation chromosome organization sister chromatid segregation positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process chromosome separation positive regulation of mitotic sister chromatid separation nuclear chromosome segregation positive regulation of chromosome separation cellular process regulation of chromosome separation organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition positive regulation of nuclear division regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization positive regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition regulation of mitotic cell cycle positive regulation of metaphase/anaphase transition of cell cycle positive regulation of mitotic cell cycle regulation of sister chromatid segregation positive regulation of cell cycle phase transition regulation of nuclear division metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition cell division	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex pericentric heterochromatin protein-DNA complex chromatin chromosome heterochromatin chromosomal region intracellular organelle organelle intracellular non-membrane-bounded organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex pericentric heterochromatin protein-DNA complex chromatin chromosome heterochromatin chromosomal region intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region non-membrane-bounded organelle membrane-bounded organelle ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex
B, D [auth E]	ANAPHASE-PROMOTING COMPLEX SUBUNIT HCN1 HCN1/CDC26,20S CYCLOSOME/APC COMPLEX PROTEIN HCN1, CHAPERONE-LIKE PROTEIN HCN1, HIGH COPY SUPPRESSOR OF CUT9 PROTEIN 1	-	regulation of cell cycle phase transition regulation of cellular process positive regulation of biological process cell cycle phase transition exit from mitosis mitotic cell cycle cellular component organization regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of exit from mitosis positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle cellular component organization or biogenesis regulation of cell cycle phase transition regulation of cellular process positive regulation of biological process cell cycle phase transition exit from mitosis mitotic cell cycle cellular component organization regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of exit from mitosis positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle cellular component organization or biogenesis regulation of cell cycle positive regulation of cellular process cell cycle process regulation of biological process mitotic nuclear division regulation of cell cycle process organelle fission biological regulation positive regulation of cell cycle regulation of mitotic cell cycle phase transition nuclear division organelle organization mitotic cell cycle process positive regulation of cell cycle phase transition cellular process regulation of exit from mitosis mitotic cell cycle phase transition organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth D]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, C [auth D]	IPR019734	Tetratricopeptide repeat	Repeat
B, D [auth E]	IPR018860	Anaphase-promoting complex, subunit CDC26	Family

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B, D [auth E]	ACE	RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 PSI-MOD : N-acetyl-L-alanine MOD:00050 , N-acetyl-L-aspartic acid MOD:00051 , N-acetyl-L-cysteine MOD:00052 , N-acetyl-S-archeol-cysteine MOD:00897 , N-acetyl-L-glutamic acid MOD:00053 , N-acetyl-L-glutamine MOD:00054 , N-acetylglycine MOD:00055 , N-acetyl-L-methionine MOD:00058 , N-acetyl-L-proline MOD:00059 , N-acetyl-L-serine MOD:00060 , N,O-diacetylated L-serine MOD:00648 , N-acetyl-L-threonine MOD:00061 , N-acetyl-L-tyrosine MOD:00062 , N-acetyl-L-valine MOD:00063 , N2-acetyl-L-arginine MOD:00359

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.