Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AMM_CoA_mutasee2xiqA4 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MM_CoA_mutaseECOD (1.6)
AB12-bindinge2xiqA3 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: CheY-likeF: B12-bindingECOD (1.6)
BMM_CoA_mutasee2xiqB4 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MM_CoA_mutaseECOD (1.6)
BB12-bindinge2xiqB3 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: CheY-likeF: B12-bindingECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.20.20.240 Alpha Beta Alpha-Beta Barrel TIM Barrel Methylmalonyl-CoA mutaseCATH (4.3.0)
A3.40.50.280 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Cobalamin-binding domainCATH (4.3.0)
B3.20.20.240 Alpha Beta Alpha-Beta Barrel TIM Barrel Methylmalonyl-CoA mutaseCATH (4.3.0)
B3.40.50.280 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Cobalamin-binding domainCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF02310B12 binding domain (B12-binding)B12 binding domainThis domain binds to B12 (adenosylcobamide)[1-3], it is found in several enzymes, such as glutamate mutase Swiss:Q05488, methionine synthase Swiss:Q99707 and methylmalonyl-CoA mutase Swiss:P22033. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, ...This domain binds to B12 (adenosylcobamide)[1-3], it is found in several enzymes, such as glutamate mutase Swiss:Q05488, methionine synthase Swiss:Q99707 and methylmalonyl-CoA mutase Swiss:P22033. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, which is important for B12 binding [2].
Domain
A, B
PF01642Methylmalonyl-CoA mutase (MM_CoA_mutase)Methylmalonyl-CoA mutase- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
METHYLMALONYL-COA MUTASE, MITOCHONDRIAL