2X1D

The crystal structure of mature acyl coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03417	e2x1dA1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Penicillin acylase, catalytic domain	F: PF03417	ECOD (1.6)
B	PF03417	e2x1dB1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Penicillin acylase, catalytic domain	F: PF03417	ECOD (1.6)
C	PF03417	e2x1dC1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Penicillin acylase, catalytic domain	F: PF03417	ECOD (1.6)
D	PF03417	e2x1dD1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Penicillin acylase, catalytic domain	F: PF03417	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.60.10	Alpha Beta	4-Layer Sandwich	Penicillin V Acylase	Chain A	CATH (4.3.0)
A	1.10.10.2120	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
B	3.60.60.10	Alpha Beta	4-Layer Sandwich	Penicillin V Acylase	Chain A	CATH (4.3.0)
B	1.10.10.2120	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
C	3.60.60.10	Alpha Beta	4-Layer Sandwich	Penicillin V Acylase	Chain A	CATH (4.3.0)
C	1.10.10.2120	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
D	3.60.60.10	Alpha Beta	4-Layer Sandwich	Penicillin V Acylase	Chain A	CATH (4.3.0)
D	1.10.10.2120	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF03417	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase (AAT)	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	ACYL-COENZYME	acyltransferase activity isopenicillin-N N-acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity N-acyltransferase activity acyl coenzyme A: isopenicillin N acyltransferase activity	penicillin biosynthetic process oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process secondary metabolic process antibiotic biosynthetic process antibiotic metabolic process organic substance metabolic process secondary metabolite biosynthetic process organic substance biosynthetic process small molecule metabolic process penicillin biosynthetic process oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process secondary metabolic process antibiotic biosynthetic process antibiotic metabolic process organic substance metabolic process secondary metabolite biosynthetic process organic substance biosynthetic process small molecule metabolic process sulfur compound metabolic process amide metabolic process beta-lactam antibiotic metabolic process organonitrogen compound metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process amide biosynthetic process lactam biosynthetic process lactam metabolic process amine metabolic process organic cyclic compound metabolic process penicillin metabolic process sulfur compound biosynthetic process biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process monocarboxylic acid metabolic process beta-lactam antibiotic biosynthetic process	peroxisomal matrix membrane-bounded organelle intracellular anatomical structure peroxisome membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle microbody lumen microbody cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR005079	Peptidase C45, hydrolase domain	Domain
A, B, C, D	IPR047794	Peptidase C45-like	Family
A, B, C, D	IPR047801	Peptidase C45	Family

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B, C, D	CSD	Parent Component: CYS RESID: AA0262 PSI-MOD : L-cysteine sulfinic acid MOD:00267

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.