Annotations: 2WYL

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF12706	e2wylA2	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: PF12706	ECOD (1.6)
B	PF12706	e2wylB2	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: PF12706	ECOD (1.6)
C	PF12706	e2wylC1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: PF12706	ECOD (1.6)
D	PF12706	e2wylD2	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: PF12706	ECOD (1.6)
E	PF12706	e2wylE2	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: PF12706	ECOD (1.6)
F	PF12706	e2wylF2	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: PF12706	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)
B	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)
C	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)
D	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)
E	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)
F	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	L-ASCORBATE-6-PHOSPHATE LACTONASE ULAG	cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding L-ascorbate 6-phosphate lactonase activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity catalytic activity	monosaccharide metabolic process catabolic process oxoacid metabolic process carbohydrate catabolic process organic acid catabolic process organic acid metabolic process L-ascorbic acid metabolic process cellular catabolic process water-soluble vitamin catabolic process organic substance metabolic process carboxylic acid catabolic process lactone catabolic process small molecule metabolic process water-soluble vitamin metabolic process monosaccharide metabolic process catabolic process oxoacid metabolic process carbohydrate catabolic process organic acid catabolic process organic acid metabolic process L-ascorbic acid metabolic process cellular catabolic process water-soluble vitamin catabolic process organic substance metabolic process carboxylic acid catabolic process lactone catabolic process small molecule metabolic process water-soluble vitamin metabolic process carbohydrate metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process L-ascorbic acid catabolic process vitamin metabolic process vitamin catabolic process organic cyclic compound catabolic process organic cyclic compound metabolic process lactone metabolic process metabolic process cellular process small molecule catabolic process monosaccharide catabolic process organic substance catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR023951	L-ascorbate-6-phosphate lactonase UlaG	Family
A, B, C, D, E A, B, C, D, E, F	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR001279	Metallo-beta-lactamase	Domain
A, B, C, D, E A, B, C, D, E, F	IPR048021	UlaG-like, metallo-hydrolase domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.