Annotations: 2WU9

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2wu9a1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	automated matches	automated matches	THALE CRESS (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
B	d2wu9b1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	automated matches	automated matches	THALE CRESS (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Thiolase_C	e2wu9A2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_C	ECOD (1.6)
A	Thiolase_N	e2wu9A1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_N	ECOD (1.6)
B	Thiolase_C	e2wu9B2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_C	ECOD (1.6)
B	Thiolase_N	e2wu9B1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
B	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02803	Thiolase, C-terminal domain (Thiolase_C)	Thiolase, C-terminal domain	Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase.	Domain
A, B	PF00108	Thiolase, N-terminal domain (Thiolase_N)	Thiolase, N-terminal domain	Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	3-KETOACYL-COA THIOLASE 2, PEROXISOMAL	acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity acetyl-CoA C-acyltransferase activity C-acyltransferase activity catalytic activity	cellular response to stimulus positive regulation of cell communication response to organic substance regulation of cellular process positive regulation of signal transduction response to stimulus response to lipid abscisic acid-activated signaling pathway signaling positive regulation of biological process regulation of signal transduction hormone-mediated signaling pathway cell communication positive regulation of response to stimulus cellular response to endogenous stimulus cellular response to stimulus positive regulation of cell communication response to organic substance regulation of cellular process positive regulation of signal transduction response to stimulus response to lipid abscisic acid-activated signaling pathway signaling positive regulation of biological process regulation of signal transduction hormone-mediated signaling pathway cell communication positive regulation of response to stimulus cellular response to endogenous stimulus response to hormone regulation of cellular response to alcohol cellular response to organic substance signal transduction positive regulation of cellular process cellular response to hormone stimulus cellular response to abscisic acid stimulus regulation of biological process regulation of signaling regulation of response to alcohol response to abscisic acid response to alcohol response to endogenous stimulus biological regulation positive regulation of abscisic acid-activated signaling pathway response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol regulation of response to stimulus response to chemical cellular response to lipid regulation of cell communication cellular process regulation of abscisic acid-activated signaling pathway positive regulation of signaling response to stress response to wounding cellular component organization peroxisome organization organelle organization plastid organization glyoxysome organization cellular component organization or biogenesis catabolic process oxoacid metabolic process organic acid catabolic process organic acid metabolic process cellular lipid catabolic process cellular catabolic process organic substance metabolic process monocarboxylic acid catabolic process fatty acid oxidation carboxylic acid catabolic process fatty acid beta-oxidation small molecule metabolic process lipid oxidation fatty acid metabolic process lipid catabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process lipid modification fatty acid catabolic process cellular lipid metabolic process metabolic process monocarboxylic acid metabolic process small molecule catabolic process organic substance catabolic process lipid metabolic process cellular biosynthetic process jasmonic acid biosynthetic process long-chain fatty acid biosynthetic process lipid biosynthetic process jasmonic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process organic substance biosynthetic process long-chain fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process fatty acid biosynthetic process biosynthetic process oxylipin metabolic process oxylipin biosynthetic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle nucleus membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle nucleus membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle peroxisome microbody glyoxysome plant-type vacuole vacuole endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002155	Thiolase	Family
A, B	IPR016039	Thiolase-like	Homologous Superfamily
A, B	IPR020617	Thiolase, C-terminal	Domain
A, B	IPR020616	Thiolase, N-terminal	Domain
A, B	IPR020613	Thiolase, conserved site	Conserved Site
A, B	IPR020610	Thiolase, active site	Active Site
A, B	IPR020615	Thiolase, acyl-enzyme intermediate active site	Active Site

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.