2WTE

The structure of the CRISPR-associated protein, Csa3, from Sulfolobus solfataricus at 1.8 angstrom resolution.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	CRISPR Csa3-like	8054246	4007634	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Winged helix DNA-binding domain	8054248	3000034	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PIN domain-like	8054247	3001041	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	PIN domain-like	8054247	3001041	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Winged helix DNA-binding domain	8054248	3000034	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08280	e2wteA2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF08280	ECOD (1.6)
A	PF22662	e2wteA1	A: a/b three-layered sandwiches	X: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	H: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	T: CARF (CRISPR-associated Rossmann fold) domains	F: PF22662	ECOD (1.6)
B	PF08280	e2wteB2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF08280	ECOD (1.6)
B	PF22662	e2wteB3	A: a/b three-layered sandwiches	X: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	H: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	T: CARF (CRISPR-associated Rossmann fold) domains	F: PF22662	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.11700	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
A	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
B	3.40.50.11700	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	CSA3	DNA binding binding organic cyclic compound binding nucleic acid binding	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR010163	CRISPR-associated CARF protein Csa3	Family
A, B	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.