2WOZ

The novel beta-propeller of the BTB-Kelch protein Krp1 provides the binding site for Lasp-1 that is necessary for pseudopodia extension

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	BTB/kelch domain-like	8084992	4003219	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Kelch motif	8084993	3000448	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01344	e2wozA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF01344	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.120.10.80	Mainly Beta	6 Propeller	Neuraminidase	Kelch-type beta propeller	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01344	Kelch motif (Kelch_1)	Kelch motif	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 10	-	plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly pseudopodium assembly cellular component organization cellular component biogenesis cellular component assembly cellular process cellular component organization or biogenesis cell projection assembly pseudopodium organization organonitrogen compound metabolic process primary metabolic process organic substance metabolic process plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly pseudopodium assembly cellular component organization cellular component biogenesis cellular component assembly cellular process cellular component organization or biogenesis cell projection assembly pseudopodium organization organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal skeletal muscle cell differentiation developmental process cellular developmental process skeletal muscle tissue development animal organ development tissue development muscle structure development skeletal muscle organ development cell differentiation anatomical structure development muscle tissue development muscle organ development regulation of biological process regulation of cellular process regulation of developmental process biological regulation regulation of cell differentiation regulation of skeletal muscle cell differentiation cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly cell development muscle cell differentiation striated muscle cell development cellular anatomical entity morphogenesis muscle cell development actin filament-based process actomyosin structure organization actin cytoskeleton organization organelle assembly anatomical structure morphogenesis myofibril assembly organelle organization anatomical structure formation involved in morphogenesis striated muscle cell differentiation supramolecular fiber organization cytoskeleton organization regulation of myoblast differentiation myoblast differentiation myoblast proliferation cell population proliferation regulation of cell population proliferation regulation of myoblast proliferation	cell projection pseudopodium cellular anatomical entity plasma membrane bounded cell projection M band intracellular anatomical structure sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber A band cytoplasm supramolecular fiber cell projection pseudopodium cellular anatomical entity plasma membrane bounded cell projection M band intracellular anatomical structure sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber A band cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle membrane-bounded organelle organelle subcompartment membrane intracellular membrane-bounded organelle endomembrane system sarcoplasm endoplasmic reticulum subcompartment bounding membrane of organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum sarcoplasmic reticulum sarcoplasmic reticulum membrane organelle membrane endoplasmic reticulum membrane cytosol cell periphery plasma membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cytoskeleton ruffle cell leading edge cullin-RING ubiquitin ligase complex protein-containing complex ubiquitin ligase complex catalytic complex transferase complex Cul3-RING ubiquitin ligase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000210	BTB/POZ domain	Domain
A	IPR015915	Kelch-type beta propeller	Homologous Superfamily
A	IPR030571	Kelch-like protein 41/41b, BTB/POZ domain	Domain
A	IPR006652	Kelch repeat type 1	Repeat
A	IPR011705	BTB/Kelch-associated	Domain
A	IPR017096	BTB-kelch protein	Family
A	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.