2WMC

Crystal structure of eukaryotic initiation factor 4E from Pisum sativum

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2wmca_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	automated matches	automated matches	GARDEN PEA (Pisum sativum ) [TaxId: 3888 ],	SCOPe (2.08)
B	d2wmcb_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	automated matches	automated matches	GARDEN PEA (Pisum sativum ) [TaxId: 3888 ],	SCOPe (2.08)
C	d2wmcc_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	automated matches	automated matches	GARDEN PEA (Pisum sativum ) [TaxId: 3888 ],	SCOPe (2.08)
D	d2wmcd_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	automated matches	automated matches	GARDEN PEA (Pisum sativum ) [TaxId: 3888 ],	SCOPe (2.08)
E	d2wmce_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	automated matches	automated matches	GARDEN PEA (Pisum sativum ) [TaxId: 3888 ],	SCOPe (2.08)
F	d2wmcf_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	automated matches	automated matches	GARDEN PEA (Pisum sativum ) [TaxId: 3888 ],	SCOPe (2.08)
G	d2wmcg_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	automated matches	automated matches	GARDEN PEA (Pisum sativum ) [TaxId: 3888 ],	SCOPe (2.08)
H	d2wmch_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	automated matches	automated matches	GARDEN PEA (Pisum sativum ) [TaxId: 3888 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Translation initiation factor eIF4e	8072941	4001578	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	eIF4e-like	8072942	3001871	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	eIF4e-like	8072942	3001871	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	eIF4e-like	8072942	3001871	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	eIF4e-like	8072942	3001871	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	eIF4e-like	8072942	3001871	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	eIF4e-like	8072942	3001871	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	eIF4e-like	8072942	3001871	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	eIF4e-like	8072942	3001871	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01652	e2wmcA1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: PF01652	ECOD (1.6)
B	PF01652	e2wmcB1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: PF01652	ECOD (1.6)
C	PF01652	e2wmcC1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: PF01652	ECOD (1.6)
D	PF01652	e2wmcD1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: PF01652	ECOD (1.6)
E	PF01652	e2wmcE1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: PF01652	ECOD (1.6)
F	PF01652	e2wmcF1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: PF01652	ECOD (1.6)
G	PF01652	e2wmcG1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: PF01652	ECOD (1.6)
H	PF01652	e2wmcH1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: PF01652	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)
B	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)
C	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)
D	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)
E	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)
F	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)
G	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)
H	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF01652	Eukaryotic initiation factor 4E (IF4E)	Eukaryotic initiation factor 4E	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding RNA binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR023398	Translation Initiation factor eIF- 4e-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR019770	Eukaryotic translation initiation factor 4E (eIF-4E), conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001040	Translation Initiation factor eIF- 4e	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.