2WL4

BIOSYNTHETIC THIOLASE FROM Z. RAMIGERA. COMPLEX OF THE H348A MUTANT WITH COENZYME A.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2wl4a1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	automated matches	(Zoogloea ramigera ) [TaxId: 350 ],	SCOPe (2.08)
A	d2wl4a2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	automated matches	automated matches	(Zoogloea ramigera ) [TaxId: 350 ],	SCOPe (2.08)
B	d2wl4b1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	automated matches	(Zoogloea ramigera ) [TaxId: 350 ],	SCOPe (2.08)
B	d2wl4b2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	automated matches	automated matches	(Zoogloea ramigera ) [TaxId: 350 ],	SCOPe (2.08)
C	d2wl4c1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	automated matches	(Zoogloea ramigera ) [TaxId: 350 ],	SCOPe (2.08)
C	d2wl4c2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	automated matches	automated matches	(Zoogloea ramigera ) [TaxId: 350 ],	SCOPe (2.08)
D	d2wl4d1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	automated matches	(Zoogloea ramigera ) [TaxId: 350 ],	SCOPe (2.08)
D	d2wl4d2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	automated matches	automated matches	(Zoogloea ramigera ) [TaxId: 350 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Thiolase-like	8043265	3000122	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Thiolase-like	8043264	3000122	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Thiolase-like	8043265	3000122	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Thiolase-like	8043264	3000122	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Thiolase-like	8043264	3000122	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Thiolase-like	8043265	3000122	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Thiolase-like	8043264	3000122	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Thiolase-like	8043265	3000122	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Thiolase_C	e2wl4A2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_C	ECOD (1.6)
A	Thiolase_N	e2wl4A1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_N	ECOD (1.6)
B	Thiolase_C	e2wl4B2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_C	ECOD (1.6)
B	Thiolase_N	e2wl4B1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_N	ECOD (1.6)
C	Thiolase_C	e2wl4C2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_C	ECOD (1.6)
C	Thiolase_N	e2wl4C1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_N	ECOD (1.6)
D	Thiolase_C	e2wl4D2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_C	ECOD (1.6)
D	Thiolase_N	e2wl4D1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
B	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
C	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
D	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02803	Thiolase, C-terminal domain (Thiolase_C)	Thiolase, C-terminal domain	Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase.	Domain
A	PF00108	Thiolase, N-terminal domain (Thiolase_N)	Thiolase, N-terminal domain	Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase.	Domain
B	PF02803	Thiolase, C-terminal domain (Thiolase_C)	Thiolase, C-terminal domain	Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase.	Domain
B	PF00108	Thiolase, N-terminal domain (Thiolase_N)	Thiolase, N-terminal domain	Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase.	Domain
C	PF02803	Thiolase, C-terminal domain (Thiolase_C)	Thiolase, C-terminal domain	Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase.	Domain
C	PF00108	Thiolase, N-terminal domain (Thiolase_N)	Thiolase, N-terminal domain	Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase.	Domain
D	PF02803	Thiolase, C-terminal domain (Thiolase_C)	Thiolase, C-terminal domain	Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase.	Domain
D	PF00108	Thiolase, N-terminal domain (Thiolase_N)	Thiolase, N-terminal domain	Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ACETYL-COA ACETYLTRANSFERASE	acetyl-CoA C-acetyltransferase activity acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity acetyl-CoA C-acyltransferase activity C-acyltransferase activity catalytic activity C-acetyltransferase activity	organic substance metabolic process poly-hydroxybutyrate biosynthetic process biosynthetic process poly(hydroxyalkanoate) biosynthetic process organic substance biosynthetic process metabolic process poly(hydroxyalkanoate) metabolic process poly-hydroxybutyrate metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity
B	ACETYL-COA ACETYLTRANSFERASE	acetyl-CoA C-acetyltransferase activity acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity acetyl-CoA C-acyltransferase activity C-acyltransferase activity catalytic activity C-acetyltransferase activity	organic substance metabolic process poly-hydroxybutyrate biosynthetic process biosynthetic process poly(hydroxyalkanoate) biosynthetic process organic substance biosynthetic process metabolic process poly(hydroxyalkanoate) metabolic process poly-hydroxybutyrate metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity
C	ACETYL-COA ACETYLTRANSFERASE	acetyl-CoA C-acetyltransferase activity acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity acetyl-CoA C-acyltransferase activity C-acyltransferase activity catalytic activity C-acetyltransferase activity	organic substance metabolic process poly-hydroxybutyrate biosynthetic process biosynthetic process poly(hydroxyalkanoate) biosynthetic process organic substance biosynthetic process metabolic process poly(hydroxyalkanoate) metabolic process poly-hydroxybutyrate metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity
D	ACETYL-COA ACETYLTRANSFERASE	acetyl-CoA C-acetyltransferase activity acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity acetyl-CoA C-acyltransferase activity C-acyltransferase activity catalytic activity C-acetyltransferase activity	organic substance metabolic process poly-hydroxybutyrate biosynthetic process biosynthetic process poly(hydroxyalkanoate) biosynthetic process organic substance biosynthetic process metabolic process poly(hydroxyalkanoate) metabolic process poly-hydroxybutyrate metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016039	Thiolase-like	Homologous Superfamily
A	IPR020617	Thiolase, C-terminal	Domain
A	IPR020616	Thiolase, N-terminal	Domain
A	IPR020613	Thiolase, conserved site	Conserved Site
A	IPR020610	Thiolase, active site	Active Site
A	IPR020615	Thiolase, acyl-enzyme intermediate active site	Active Site
A	IPR002155	Thiolase	Family
B	IPR016039	Thiolase-like	Homologous Superfamily
B	IPR020617	Thiolase, C-terminal	Domain
B	IPR020616	Thiolase, N-terminal	Domain
B	IPR020613	Thiolase, conserved site	Conserved Site
B	IPR020610	Thiolase, active site	Active Site
B	IPR020615	Thiolase, acyl-enzyme intermediate active site	Active Site
B	IPR002155	Thiolase	Family
C	IPR016039	Thiolase-like	Homologous Superfamily
C	IPR020617	Thiolase, C-terminal	Domain
C	IPR020616	Thiolase, N-terminal	Domain
C	IPR020613	Thiolase, conserved site	Conserved Site
C	IPR020610	Thiolase, active site	Active Site
C	IPR020615	Thiolase, acyl-enzyme intermediate active site	Active Site
C	IPR002155	Thiolase	Family
D	IPR016039	Thiolase-like	Homologous Superfamily
D	IPR020617	Thiolase, C-terminal	Domain
D	IPR020616	Thiolase, N-terminal	Domain
D	IPR020613	Thiolase, conserved site	Conserved Site
D	IPR020610	Thiolase, active site	Active Site
D	IPR020615	Thiolase, acyl-enzyme intermediate active site	Active Site
D	IPR002155	Thiolase	Family

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	CSD	Parent Component: CYS RESID: AA0262 PSI-MOD : L-cysteine sulfinic acid MOD:00267
B	CSD	Parent Component: CYS RESID: AA0262 , AA0262 PSI-MOD : L-cysteine sulfinic acid MOD:00267 , L-cysteine sulfinic acid MOD:00267
B	CSO	Parent Component: CYS RESID: AA0262 , AA0262 , AA0205 PSI-MOD : L-cysteine sulfinic acid MOD:00267 , L-cysteine sulfinic acid MOD:00267 , L-cysteine sulfenic acid MOD:00210
D	CSO	Parent Component: CYS RESID: AA0262 , AA0262 , AA0205 , AA0205 PSI-MOD : L-cysteine sulfinic acid MOD:00267 , L-cysteine sulfinic acid MOD:00267 , L-cysteine sulfenic acid MOD:00210 , L-cysteine sulfenic acid MOD:00210