Annotations: 2WL1

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2wl1a_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PRY/SPRY domain	8060017	4001665	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Concanavalin A-like lectins/glucanases	8060018	3000120	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00622,PF13765	e2wl1A1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00622,PF13765	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.920	Mainly Beta	Sandwich	Jelly Rolls	SPRY domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00622	SPRY domain (SPRY)	SPRY domain	-	Family
A	PF13765	SPRY-associated domain (PRY)	SPRY-associated domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PYRIN	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity cytoskeletal protein binding actin binding protein binding binding cation binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity cytoskeletal protein binding actin binding protein binding binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding identical protein binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization pyroptosome complex assembly protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of biological process regulation of primary metabolic process positive regulation of molecular function cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization pyroptosome complex assembly protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of biological process regulation of primary metabolic process positive regulation of molecular function positive regulation of metabolic process organic substance metabolic process regulation of proteolysis proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process protein metabolic process regulation of cysteine-type endopeptidase activity regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process regulation of peptidase activity biological regulation positive regulation of catalytic activity primary metabolic process regulation of macromolecule metabolic process regulation of molecular function positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis metabolic process macromolecule metabolic process regulation of metabolic process regulation of defense response response to stimulus regulation of response to external stimulus defense response response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response cellular response to stimulus positive regulation of response to biotic stimulus regulation of cellular process pattern recognition receptor signaling pathway regulation of NLRP3 inflammasome complex assembly negative regulation of biological process regulation of signal transduction response to biotic stimulus cell communication immune response-activating signaling pathway inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly regulation of immune system process signal transduction negative regulation of NLRP3 inflammasome complex assembly positive regulation of immune system process innate immune response-activating signaling pathway negative regulation of cellular component organization immune response response to other organism regulation of innate immune response regulation of inflammasome-mediated signaling pathway negative regulation of protein-containing complex assembly defense response to other organism regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular component organization intracellular receptor signaling pathway signaling negative regulation of signaling negative regulation of cytoplasmic pattern recognition receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway negative regulation of cell communication regulation of protein-containing complex assembly immune response-regulating signaling pathway innate immune response negative regulation of cellular process response to external biotic stimulus regulation of signaling positive regulation of innate immune response negative regulation of response to stimulus defense response to symbiont regulation of cellular component biogenesis negative regulation of signal transduction negative regulation of immune system process immune system process regulation of cell communication negative regulation of inflammasome-mediated signaling pathway regulation of biosynthetic process cellular biosynthetic process cellular metabolic process regulation of cellular metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process pyroptosis cell death programmed cell death negative regulation of inflammatory response negative regulation of response to external stimulus negative regulation of defense response multicellular organismal process interleukin-1 production regulation of interleukin-1 beta production negative regulation of cellular metabolic process negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production regulation of cytokine production cytokine production regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of interleukin-1 production negative regulation of metabolic process negative regulation of cytokine production negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process interleukin-1 beta production negative regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of interleukin-1 beta production positive regulation of biosynthetic process positive regulation of interleukin-1 production positive regulation of cellular process positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production positive regulation of cellular biosynthetic process response to organic substance response to type II interferon response to cytokine response to chemical regulation of interleukin-12 production negative regulation of interleukin-12 production interleukin-12 production positive regulation of autophagy catabolic process autophagy regulation of catabolic process regulation of autophagy cellular catabolic process positive regulation of catabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process process utilizing autophagic mechanism negative regulation of chemokine production negative regulation of macrophage inflammatory protein 1 alpha production macrophage inflammatory protein-1 alpha production regulation of macrophage inflammatory protein 1 alpha production regulation of chemokine production chemokine production regulation of cytokine production involved in inflammatory response negative regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasmic vesicle intracellular vesicle vesicle vacuole autophagosome ruffle protein-containing complex cytoskeleton intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex canonical inflammasome complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR006574	SPRY-associated	Domain
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR043136	B30.2/SPRY domain superfamily	Homologous Superfamily
A	IPR004020	DAPIN domain	Domain
A	IPR003877	SPRY domain	Domain
A	IPR011029	Death-like domain superfamily	Homologous Superfamily
A	IPR000315	B-box-type zinc finger	Domain
A	IPR001870	B30.2/SPRY domain	Domain
A	IPR003879	Butyrophylin-like, SPRY domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O15553	familial Mediterranean fever familial Mediterranean fever, autosomal dominant psoriatic arthritis amyloidosis autosomal recessive familial Mediterranean fever Behcet disease psoriasis acne ankylosing spondylitis autosomal dominant familial periodic fever brucellosis intermittent hydrarthrosis periodic fever syndrome acquired metabolic disease attention deficit hyperactivity disorder, inattentive type familial Mediterranean fever familial Mediterranean fever, autosomal dominant psoriatic arthritis amyloidosis autosomal recessive familial Mediterranean fever Behcet disease psoriasis acne ankylosing spondylitis autosomal dominant familial periodic fever brucellosis intermittent hydrarthrosis periodic fever syndrome acquired metabolic disease attention deficit hyperactivity disorder, inattentive type familial cold autoinflammatory syndrome hidradenitis suppurativa mevalonic aciduria Periodic syndrome pyoderma gangrenosum autoimmune disease Muckle-Wells syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.