Annotations: 2WFH

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2wfha_	Alpha and beta proteins (a/b)	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	L domain-like	automated matches	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2wfhb_	Alpha and beta proteins (a/b)	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	L domain-like	automated matches	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Ngr ectodomain-like	8061073	4002278	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	L domain-like	8096003	3001010	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	L domain-like	8096003	3001010	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LRR_8_1	e2wfhA1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)
B	LRR_8_1	e2wfhB1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
B	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
A, B	PF01462	Leucine rich repeat N-terminal domain (LRRNT)	Leucine rich repeat N-terminal domain	-	Family
A, B	PF01463	Leucine rich repeat C-terminal domain (LRRCT)	Leucine rich repeat C-terminal domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	SLIT HOMOLOG 2 PROTEIN C-PRODUCT	GTPase regulator activity enzyme regulator activity GTPase inhibitor activity molecular function inhibitor activity nucleoside-triphosphatase regulator activity molecular function regulator activity enzyme inhibitor activity identical protein binding protein binding binding cation binding ion binding calcium ion binding metal ion binding GTPase regulator activity enzyme regulator activity GTPase inhibitor activity molecular function inhibitor activity nucleoside-triphosphatase regulator activity molecular function regulator activity enzyme inhibitor activity identical protein binding protein binding binding cation binding ion binding calcium ion binding metal ion binding small molecule binding signaling receptor binding Roundabout binding protein homodimerization activity protein dimerization activity proteoglycan binding carbohydrate derivative binding extracellular matrix binding laminin-1 binding laminin binding heparin binding glycosaminoglycan binding sulfur compound binding	developmental process heart development multicellular organismal process cardiac chamber morphogenesis animal organ development heart morphogenesis ventricular septum development circulatory system development multicellular organism development anatomical structure morphogenesis cardiac septum development cardiac septum morphogenesis ventricular septum morphogenesis cardiac chamber development anatomical structure development developmental process heart development multicellular organismal process cardiac chamber morphogenesis animal organ development heart morphogenesis ventricular septum development circulatory system development multicellular organism development anatomical structure morphogenesis cardiac septum development cardiac septum morphogenesis ventricular septum morphogenesis cardiac chamber development anatomical structure development animal organ morphogenesis cardiac ventricle development system development negative regulation of locomotion regulation of biological process regulation of cell motility regulation of cellular process regulation of smooth muscle cell migration biological regulation negative regulation of biological process smooth muscle cell migration muscle cell migration negative regulation of smooth muscle cell migration regulation of locomotion regulation of cell migration negative regulation of cellular process negative regulation of cell motility cell migration cellular process cell motility locomotion negative regulation of cell migration epithelium development tube development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue development tissue morphogenesis tube morphogenesis morphogenesis of a branching structure epithelial tube morphogenesis morphogenesis of a branching epithelium cellular response to stimulus negative regulation of mononuclear cell migration negative regulation of leukocyte chemotaxis response to stimulus regulation of response to external stimulus negative regulation of chemotaxis negative regulation of monocyte chemotaxis regulation of monocyte chemotaxis taxis myeloid leukocyte migration regulation of immune system process regulation of mononuclear cell migration cell chemotaxis chemotaxis regulation of leukocyte chemotaxis negative regulation of response to stimulus regulation of leukocyte migration response to external stimulus regulation of chemotaxis monocyte chemotaxis leukocyte migration cellular response to chemical stimulus negative regulation of leukocyte migration negative regulation of immune system process regulation of response to stimulus immune system process response to chemical negative regulation of response to external stimulus mononuclear cell migration leukocyte chemotaxis regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process negative regulation of phosphorylation regulation of metabolic process positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death positive regulation of cellular process positive regulation of nervous system development axonogenesis cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation positive regulation of cell projection organization regulation of cell projection organization positive regulation of cell development nervous system development generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development cell morphogenesis cellular component organization regulation of nervous system development neurogenesis positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process cellular component organization or biogenesis positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of multicellular organismal development plasma membrane bounded cell projection organization axon development cell morphogenesis involved in neuron differentiation neuron development regulation of plasma membrane bounded cell projection organization regulation of growth growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth cellular response to growth factor stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of cellular response to growth factor stimulus cellular response to endogenous stimulus response to growth factor cell migration involved in sprouting angiogenesis endothelial cell migration angiogenesis tissue migration ameboidal-type cell migration blood vessel endothelial cell migration epithelial cell migration blood vessel development blood vessel morphogenesis sprouting angiogenesis vasculature development epithelium migration anatomical structure formation involved in morphogenesis response to organic substance response to ketone response to lipid response to alcohol response to cortisol response to glucocorticoid response to oxygen-containing compound response to corticosteroid response to hormone response to steroid hormone response to organic cyclic compound negative regulation of vascular permeability regulation of vascular permeability system process circulatory system process vascular process in circulatory system regulation of biological quality blood circulation negative chemotaxis cellular response to nitrogen compound response to heparin response to organonitrogen compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to organonitrogen compound cellular response to heparin cellular response to organic substance ovulation cycle process reproductive process sex differentiation development of primary female sexual characteristics developmental process involved in reproduction ovulation cycle apoptotic process involved in development development of primary sexual characteristics reproductive structure development luteolysis rhythmic process gonad development reproductive system development female gonad development multicellular organismal reproductive process female sex differentiation apoptotic process involved in luteolysis axon extension developmental growth axon extension involved in axon guidance neuron projection extension involved in neuron projection guidance neuron projection extension developmental cell growth axon guidance developmental growth involved in morphogenesis neuron projection guidance retinal ganglion cell axon guidance neutrophil migration granulocyte migration regulation of neutrophil chemotaxis regulation of neutrophil migration negative regulation of neutrophil chemotaxis neutrophil chemotaxis regulation of granulocyte chemotaxis negative regulation of granulocyte chemotaxis granulocyte chemotaxis negative regulation of neutrophil migration small GTPase-mediated signal transduction signaling negative regulation of signaling regulation of small GTPase mediated signal transduction negative regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling negative regulation of small GTPase mediated signal transduction negative regulation of signal transduction regulation of cell communication motor neuron axon guidance cellular response to hormone stimulus regulation of smooth muscle cell chemotaxis smooth muscle cell chemotaxis negative regulation of smooth muscle cell chemotaxis positive regulation of locomotion regulation of negative chemotaxis positive regulation of chemotaxis positive regulation of negative chemotaxis positive regulation of response to stimulus positive regulation of response to external stimulus induction of negative chemotaxis regulation of cytoskeleton organization regulation of actin filament-based process regulation of cellular component size cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly actin filament-based process negative regulation of protein polymerization regulation of actin filament polymerization negative regulation of supramolecular fiber organization negative regulation of actin filament polymerization protein polymerization actin polymerization or depolymerization regulation of actin filament organization actin filament polymerization actin cytoskeleton organization negative regulation of cellular component organization protein-containing complex organization negative regulation of cytoskeleton organization actin filament organization regulation of actin polymerization or depolymerization regulation of cellular component biogenesis regulation of organelle organization negative regulation of protein-containing complex assembly organelle organization negative regulation of organelle organization regulation of protein polymerization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization regulation of anatomical structure size heart valve development aortic valve development heart valve morphogenesis semi-lunar valve development aortic valve morphogenesis ureteric bud development mesonephric epithelium development kidney epithelium development mesonephros development renal system development kidney development mesonephric tubule development regulation of chemokine-mediated signaling pathway response to cytokine response to chemokine cytokine-mediated signaling pathway cellular response to chemokine negative regulation of G protein-coupled receptor signaling pathway chemokine-mediated signaling pathway cellular response to cytokine stimulus regulation of G protein-coupled receptor signaling pathway cell surface receptor signaling pathway regulation of cytokine-mediated signaling pathway negative regulation of chemokine-mediated signaling pathway regulation of response to cytokine stimulus negative regulation of response to cytokine stimulus negative regulation of cytokine-mediated signaling pathway G protein-coupled receptor signaling pathway pulmonary valve morphogenesis pulmonary valve development plasma membrane bounded cell projection assembly negative regulation of plasma membrane bounded cell projection assembly regulation of lamellipodium assembly regulation of lamellipodium organization negative regulation of cell projection organization negative regulation of lamellipodium assembly lamellipodium assembly regulation of cell projection assembly regulation of plasma membrane bounded cell projection assembly negative regulation of lamellipodium organization lamellipodium organization cell projection assembly negative regulation of endothelial cell migration negative regulation of epithelial cell migration regulation of endothelial cell migration regulation of epithelial cell migration negative regulation of multicellular organismal process olfactory bulb interneuron differentiation forebrain development cerebral cortex development cerebral cortex tangential migration using cell-cell interactions telencephalon cell migration forebrain cell migration olfactory bulb development substrate-dependent cerebral cortex tangential migration cerebral cortex cell migration head development olfactory lobe development brain development chemorepulsion involved in postnatal olfactory bulb interneuron migration pallium development tangential migration from the subventricular zone to the olfactory bulb cerebral cortex tangential migration central nervous system development olfactory bulb interneuron development substrate-dependent cell migration telencephalon development postnatal olfactory bulb interneuron migration regulation of axon guidance regulation of retinal ganglion cell axon guidance negative regulation of retinal ganglion cell axon guidance negative regulation of axon guidance negative regulation of neuron projection development Roundabout signaling pathway central nervous system neuron development corticospinal neuron axon guidance through spinal cord central nervous system neuron differentiation corticospinal neuron axon guidance central nervous system projection neuron axonogenesis central nervous system neuron axonogenesis corticospinal tract morphogenesis	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
A, B	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B	IPR013032	EGF-like, conserved site	Conserved Site
A, B	IPR001611	Leucine-rich repeat	Repeat
A, B	IPR003645	Follistatin-like, N-terminal	Domain
A, B	IPR001881	EGF-like calcium-binding domain	Domain
A, B	IPR000483	Cysteine-rich flanking region, C-terminal	Domain
A, B	IPR000372	Leucine-rich repeat N-terminal domain	Domain
A, B	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A, B	IPR000742	EGF-like domain	Domain
A, B	IPR001791	Laminin G domain	Domain
A, B	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A, B	IPR006207	Cystine knot, C-terminal	Domain
A, B	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O94813	small cell lung carcinoma temporal lobe epilepsy malignant ependymoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma adrenal cortex carcinoma pituitary cancer atopic eczema breast carcinoma cystic fibrosis glioblastoma invasive ductal breast carcinoma lung cancer malignant glioma small cell lung carcinoma temporal lobe epilepsy malignant ependymoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma adrenal cortex carcinoma pituitary cancer atopic eczema breast carcinoma cystic fibrosis glioblastoma invasive ductal breast carcinoma lung cancer malignant glioma non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Alzheimer disease small cell carcinoma attention deficit hyperactivity disorder, inattentive type breast fibroadenoma Epilepsy, Benign Psychomotor, Childhood hepatocellular carcinoma lung carcinoma malignant pancreatic neoplasm oligodendroglioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia astrocytic tumor atypical teratoid rhabdoid tumor congenital anomaly of kidney and urinary tract interstitial cystitis lung adenocarcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.