2W69

Influenza polymerase fragment

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2w69a1	Alpha and beta proteins (a/b)	Restriction endonuclease-like	Restriction endonuclease-like	PA N-terminal domain	automated matches	(Influenza A virus ) [TaxId: 11320 ],	SCOPe (2.08)
A	d2w69a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus ) [TaxId: 11320 ],	SCOPe (2.08)
B	d2w69b1	Alpha and beta proteins (a/b)	Restriction endonuclease-like	Restriction endonuclease-like	PA N-terminal domain	automated matches	(Influenza A virus ) [TaxId: 11320 ],	SCOPe (2.08)
B	d2w69b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus ) [TaxId: 11320 ],	SCOPe (2.08)
C [auth D]	d2w69d1	Alpha and beta proteins (a/b)	Restriction endonuclease-like	Restriction endonuclease-like	PA N-terminal domain	automated matches	(Influenza A virus ) [TaxId: 11320 ],	SCOPe (2.08)
C [auth D]	d2w69d2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus ) [TaxId: 11320 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00603	e2w69A1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: PF00603	ECOD (1.6)
B	PF00603	e2w69B1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: PF00603	ECOD (1.6)
C [auth D]	PF00603	e2w69D1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: PF00603	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C [auth D]	PF00603	Influenza RNA-dependent RNA polymerase subunit PA (Flu_PA)	Influenza RNA-dependent RNA polymerase subunit PA	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C [auth D]	POLYMERASE ACIDIC PROTEIN	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	cellular biosynthetic process cellular metabolic process RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process viral genome replication biosynthetic process cellular biosynthetic process cellular metabolic process RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process viral genome replication biosynthetic process viral RNA genome replication organic cyclic compound biosynthetic process viral process organic substance biosynthetic process metabolic process cellular process macromolecule metabolic process viral gene expression cap snatching negative stranded viral RNA transcription viral transcription RNA-templated viral transcription gene expression DNA-templated transcription symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host transcription symbiont-mediated suppression of host gene expression symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity modulation by symbiont of host process symbiont-mediated perturbation of host gene expression symbiont-mediated perturbation of host transcription modulation of process of another organism	host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle host cell cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C [auth D]	IPR001009	Influenza RNA-dependent RNA polymerase subunit PA	Family
A, B, C [auth D]	IPR037534	Polymerase acidic protein	Family
A, B, C [auth D]	IPR038372	Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.