2W3N

Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	beta-carbonic anhydrase cab	8082605	3000468	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	beta-carbonic anhydrase cab	8082605	3000468	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	beta-carbonic anhydrase cab	8082605	3000468	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pro_CA	e2w3nA1	A: a/b three-layered sandwiches	X: beta-carbonic anhydrase-like	H: beta-carbonic anhydrase (From Topology)	T: beta-carbonic anhydrase	F: Pro_CA	ECOD (1.6)
B	Pro_CA	e2w3nB1	A: a/b three-layered sandwiches	X: beta-carbonic anhydrase-like	H: beta-carbonic anhydrase (From Topology)	T: beta-carbonic anhydrase	F: Pro_CA	ECOD (1.6)
C	Pro_CA	e2w3nC1	A: a/b three-layered sandwiches	X: beta-carbonic anhydrase-like	H: beta-carbonic anhydrase (From Topology)	T: beta-carbonic anhydrase	F: Pro_CA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.140.610	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
A	3.40.1050.10	Alpha Beta	3-Layer(aba) Sandwich	Beta-carbonic Anhydrase	Chain A	CATH (4.3.0)
B	6.10.140.610	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
B	3.40.1050.10	Alpha Beta	3-Layer(aba) Sandwich	Beta-carbonic Anhydrase	Chain A	CATH (4.3.0)
C	6.10.140.610	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
C	3.40.1050.10	Alpha Beta	3-Layer(aba) Sandwich	Beta-carbonic Anhydrase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00484	Carbonic anhydrase (Pro_CA)	Carbonic anhydrase	This family includes carbonic anhydrases as well as a family of non-functional homologues related to YbcF.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	CARBONIC ANHYDRASE 2	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding carbonate dehydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR001765	Carbonic anhydrase	Family
A, B, C	IPR036874	Carbonic anhydrase superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.