Annotations: 2W18

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	WD40 repeat-like	8092868	3001694	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF16756	e2w18A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF16756	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16756	Partner and localizer of BRCA2 WD40 domain (PALB2_WD40)	Partner and localizer of BRCA2 WD40 domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PARTNER AND LOCALIZER OF BRCA2	DNA binding binding organic cyclic compound binding nucleic acid binding	developmental process multicellular organism development multicellular organismal process anatomical structure development animal organ development embryonic organ development embryo development anatomical structure morphogenesis animal organ morphogenesis cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process developmental process multicellular organism development multicellular organismal process anatomical structure development animal organ development embryonic organ development embryo development anatomical structure morphogenesis animal organ morphogenesis cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair tissue development mesoderm development somitogenesis epithelium development chordate embryonic development segmentation anterior/posterior pattern specification pattern specification process regionalization embryo development ending in birth or egg hatching somite development anatomical structure formation involved in morphogenesis regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death multicellular organism growth developmental growth growth inner cell mass cell proliferation cell population proliferation in utero embryonic development blastocyst growth blastocyst development post-anal tail morphogenesis	protein-containing complex catalytic complex DNA repair complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm protein-containing complex catalytic complex DNA repair complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR031920	Partner and localiser of BRCA2, WD40 domain	Domain
A	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A	IPR042417	Partner and localizer of BRCA2	Family
A	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q86YC2	Fanconi anemia breast cancer Fanconi anemia complementation group N ovarian cancer cancer prostate cancer hereditary breast ovarian cancer syndrome medulloblastoma breast carcinoma hereditary breast carcinoma Hereditary Nonpolyposis Colorectal Cancer intellectual disability Lynch syndrome acute myeloid leukemia BAP1-related tumor predisposition syndrome Fanconi anemia breast cancer Fanconi anemia complementation group N ovarian cancer cancer prostate cancer hereditary breast ovarian cancer syndrome medulloblastoma breast carcinoma hereditary breast carcinoma Hereditary Nonpolyposis Colorectal Cancer intellectual disability Lynch syndrome acute myeloid leukemia BAP1-related tumor predisposition syndrome ovarian neoplasm pancreatic neoplasm familial pancreatic carcinoma kidney Wilms tumor adrenal cortex carcinoma malignant pancreatic neoplasm bipolar disorder pancreatic cancer, susceptibility to, 3 congenital anemia esophageal atresia/tracheoesophageal fistula familial prostate carcinoma schizophrenia hematopoietic and lymphoid system neoplasm inherited aplastic anemia lung cancer aplastic anemia breast adenocarcinoma ovarian carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia prostate adenocarcinoma exocrine pancreatic carcinoma psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.