2W01

Crystal structure of the guanylyl cyclase Cya2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2w01a_	Alpha and beta proteins (a+b)	Ferredoxin-like	Nucleotide cyclase	automated matches	automated matches	(Synechocystis sp. PCC 6803 ) [TaxId: 1148 ],	SCOPe (2.08)
B	d2w01b_	Alpha and beta proteins (a+b)	Ferredoxin-like	Nucleotide cyclase	automated matches	automated matches	(Synechocystis sp. PCC 6803 ) [TaxId: 1148 ],	SCOPe (2.08)
C	d2w01c_	Alpha and beta proteins (a+b)	Ferredoxin-like	Nucleotide cyclase	automated matches	automated matches	(Synechocystis sp. PCC 6803 ) [TaxId: 1148 ],	SCOPe (2.08)
D	d2w01d_	Alpha and beta proteins (a+b)	Ferredoxin-like	Nucleotide cyclase	automated matches	automated matches	(Synechocystis sp. PCC 6803 ) [TaxId: 1148 ],	SCOPe (2.08)
E	d2w01e_	Alpha and beta proteins (a+b)	Ferredoxin-like	Nucleotide cyclase	automated matches	automated matches	(Synechocystis sp. PCC 6803 ) [TaxId: 1148 ],	SCOPe (2.08)
F	d2w01f_	Alpha and beta proteins (a+b)	Ferredoxin-like	Nucleotide cyclase	automated matches	automated matches	(Synechocystis sp. PCC 6803 ) [TaxId: 1148 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8064528	3001272	SCOP2B (2022-06-29)
B	SCOP2 Family	Adenylyl and guanylyl cyclase catalytic domain	8064527	4001316	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8064528	3001272	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8064528	3001272	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8064528	3001272	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8064528	3001272	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8064528	3001272	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00211	e2w01A1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: PF00211	ECOD (1.6)
B	PF00211	e2w01B1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: PF00211	ECOD (1.6)
C	PF00211	e2w01C1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: PF00211	ECOD (1.6)
D	PF00211	e2w01D1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: PF00211	ECOD (1.6)
E	PF00211	e2w01E1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: PF00211	ECOD (1.6)
F	PF00211	e2w01F1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: PF00211	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.70.1230	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Nucleotide cyclase, GGDEF domain	CATH (4.3.0)
B	3.30.70.1230	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Nucleotide cyclase, GGDEF domain	CATH (4.3.0)
C	3.30.70.1230	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Nucleotide cyclase, GGDEF domain	CATH (4.3.0)
D	3.30.70.1230	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Nucleotide cyclase, GGDEF domain	CATH (4.3.0)
E	3.30.70.1230	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Nucleotide cyclase, GGDEF domain	CATH (4.3.0)
F	3.30.70.1230	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Nucleotide cyclase, GGDEF domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00211	Adenylate and Guanylate cyclase catalytic domain (Guanylate_cyc)	Adenylate and Guanylate cyclase catalytic domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	ADENYLATE CYCLASE	phosphorus-oxygen lyase activity cyclase activity lyase activity adenylate cyclase activity catalytic activity identical protein binding protein binding binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cellular process signal transduction intracellular signal transduction cell communication nucleotide biosynthetic process cyclic nucleotide metabolic process nucleobase-containing compound metabolic process organic substance metabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cellular process signal transduction intracellular signal transduction cell communication nucleotide biosynthetic process cyclic nucleotide metabolic process nucleobase-containing compound metabolic process organic substance metabolic process nucleobase-containing small molecule metabolic process cyclic nucleotide biosynthetic process organic substance biosynthetic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process nucleoside phosphate metabolic process cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleotide metabolic process organic cyclic compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process metabolic process	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	Domain
A, B, C, D, E A, B, C, D, E, F	IPR007890	CHASE2	Domain
A, B, C, D, E A, B, C, D, E, F	IPR029787	Nucleotide cyclase	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.