Annotations: 2VXG

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21289	e2vxgA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF21289	ECOD (1.6)
B	PF21289	e2vxgB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF21289	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.140.270	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
A	1.10.220.100	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
B	6.10.140.270	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
B	1.10.220.100	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21289	Enhancer of mRNA-decapping protein 4, C-terminal (EDC4_C)	Enhancer of mRNA-decapping protein 4, C-terminal	Enhancer of mRNA-decapping protein 4 (EDC4, also known as Ge-1), is a regulator of mRNA decapping to function in the mRNA P-bodies within the cytoplasm. It has been shown to interact with mTORC1 [2], coenzyme A synthase [3] and MARF1 [4]. It is also ...	Enhancer of mRNA-decapping protein 4 (EDC4, also known as Ge-1), is a regulator of mRNA decapping to function in the mRNA P-bodies within the cytoplasm. It has been shown to interact with mTORC1 [2], coenzyme A synthase [3] and MARF1 [4]. It is also involved in the regulation of immune system [5]. This is the C-terminal domain which is necessary and sufficient for P-body targeting and in plants, it also mediates DCP1 and DCP2 interaction, as well as self-association [5,6]. It adopts an helical-repeat fold similar to that of ARM/HEAT repeat proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	CG6181-PA, ISOFORM A	-	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process negative regulation of metabolic process positive regulation of mRNA metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process nucleobase-containing compound catabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process deadenylation-dependent decapping of nuclear-transcribed mRNA regulation of metabolic process RNA decapping nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay catabolic process cellular biosynthetic process positive regulation of biological process RNA metabolic process macromolecule catabolic process mRNA destabilization organic substance metabolic process regulation of mRNA catabolic process negative regulation of cellular process mRNA methylguanosine-cap decapping negative regulation of macromolecule metabolic process regulation of biosynthetic process nuclear-transcribed mRNA catabolic process RNA destabilization biological regulation regulation of macromolecule metabolic process regulation of catabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process regulation of cellular biosynthetic process positive regulation of catabolic process regulation of mRNA stability negative regulation of biosynthetic process positive regulation of mRNA catabolic process regulation of RNA stability cellular process regulation of mRNA metabolic process organic substance catabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to fungus defense response to other organism response to stress response to external biotic stimulus response to fungus nuclear-transcribed mRNA catabolic process, deadenylation-independent decay deadenylation-independent decapping of nuclear-transcribed mRNA cellular component biogenesis cellular component organization organelle organization cellular component assembly organelle assembly P-body assembly non-membrane-bounded organelle assembly cellular component organization or biogenesis regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA-mediated gene silencing miRNA-mediated post-transcriptional gene silencing post-transcriptional gene silencing multicellular organismal process blastoderm segmentation anterior/posterior pattern specification anterior/posterior axis specification, embryo cellular process involved in reproduction in multicellular organism female gamete generation pole plasm oskar mRNA localization oocyte development multicellular organism development localization cell differentiation cellular macromolecule localization anatomical structure development cell maturation RNA localization pole plasm mRNA localization developmental process pole plasm RNA localization embryonic pattern specification oocyte anterior/posterior axis specification developmental maturation cytoplasm organization anatomical structure maturation maternal determination of anterior/posterior axis, embryo germ cell development intracellular mRNA localization involved in anterior/posterior axis specification axis specification cellular localization sexual reproduction cellular developmental process reproductive process segmentation pattern specification process cell development developmental process involved in reproduction embryo development gamete generation tripartite regional subdivision embryonic axis specification anterior/posterior axis specification oocyte axis specification oocyte construction intracellular mRNA localization multicellular organismal reproductive process oogenesis regionalization pole plasm assembly intracellular mRNA localization involved in pattern specification process macromolecule localization oocyte differentiation	intracellular anatomical structure cytoplasmic ribonucleoprotein granule cellular anatomical entity ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex P-body non-membrane-bounded organelle pole plasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR045152	Enhancer of mRNA-decapping protein 4-like	Family
A, B	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, B	IPR044938	Enhancer of mRNA-decapping protein 4, conserved C-terminal domain superfamily	Homologous Superfamily
A, B	IPR001680	WD40 repeat	Repeat
A, B	IPR049404	Enhancer of mRNA-decapping protein 4, C-terminal	Domain
A, B	IPR032401	Enhancer of mRNA-decapping protein 4, WD40 repeat region	Domain
A, B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.