2VWA

Crystal structure of a sporozoite protein essential for liver stage development of malaria parasite

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Pfg27 structural repeat-like	8102983	3001646	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Pfg27 structural repeat-like	8102983	3001646	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Pfg27 structural repeat-like	8102983	3001646	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Pfg27 structural repeat-like	8102983	3001646	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Pfg27 structural repeat-like	8102983	3001646	SCOP2B (2022-06-29)
F	SCOP2 Family	Uis3 lipid-binding domain-like	8046667	4005228	SCOP2 (2022-06-29)
F	SCOP2 Superfamily	Pfg27 structural repeat-like	8102983	3001646	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF11567	e2vwaA1	A: alpha bundles	X: Gametocyte protein Pfg27-related (From Homology)	H: Gametocyte protein Pfg27-related	T: Sporozoite protein UIS3 soluble domain	F: PF11567	ECOD (1.6)
B	PF11567	e2vwaB1	A: alpha bundles	X: Gametocyte protein Pfg27-related (From Homology)	H: Gametocyte protein Pfg27-related	T: Sporozoite protein UIS3 soluble domain	F: PF11567	ECOD (1.6)
C	PF11567	e2vwaC1	A: alpha bundles	X: Gametocyte protein Pfg27-related (From Homology)	H: Gametocyte protein Pfg27-related	T: Sporozoite protein UIS3 soluble domain	F: PF11567	ECOD (1.6)
D	PF11567	e2vwaD1	A: alpha bundles	X: Gametocyte protein Pfg27-related (From Homology)	H: Gametocyte protein Pfg27-related	T: Sporozoite protein UIS3 soluble domain	F: PF11567	ECOD (1.6)
E	PF11567	e2vwaE1	A: alpha bundles	X: Gametocyte protein Pfg27-related (From Homology)	H: Gametocyte protein Pfg27-related	T: Sporozoite protein UIS3 soluble domain	F: PF11567	ECOD (1.6)
F	PF11567	e2vwaF1	A: alpha bundles	X: Gametocyte protein Pfg27-related (From Homology)	H: Gametocyte protein Pfg27-related	T: Sporozoite protein UIS3 soluble domain	F: PF11567	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.1330	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.20.58.1330	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
C	1.20.58.1330	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
D	1.20.58.1330	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
E	1.20.58.1330	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
F	1.20.58.1330	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF11567	Plasmodium falciparum UIS3 membrane protein (PfUIS3)	Plasmodium falciparum UIS3 membrane protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	PUTATIVE UNCHARACTERIZED PROTEIN PF13_0012	-	-	membrane cellular anatomical entity membrane-bounded organelle host cellular component host intracellular part extracellular organelle extracellular region symbiont-containing vacuole membrane host cell cytoplasm part symbiont-containing vacuole host cell cytoplasm host cell part organelle host intracellular region membrane cellular anatomical entity membrane-bounded organelle host cellular component host intracellular part extracellular organelle extracellular region symbiont-containing vacuole membrane host cell cytoplasm part symbiont-containing vacuole host cell cytoplasm host cell part organelle host intracellular region extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR021626	Plasmodium falciparum UIS3 membrane protein	Family
A, B, C, D, E A, B, C, D, E, F	IPR006389	Early transcribed membrane protein, plasmodium	Family
A, B, C, D, E A, B, C, D, E, F	IPR038403	Plasmodium falciparum UIS3, C-terminal domain superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F	OPM	Monotopic/peripheral	All alpha monotopic/peripheral	Saposin-like	Malarial early transcribed membrane protein

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.