2VS1
The crystal structure of Pyrococcus abyssi tRNA (uracil-54, C5)- methyltransferase in complex with S-adenosyl-L-homocysteine
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF21579 | e2vs1A1 | A: beta barrels | X: OB-fold | H: Nucleic acid-binding proteins (From Topology) | T: Nucleic acid-binding proteins | F: PF21579 | ECOD (1.6) |
A | PF05958 | e2vs1A2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PF05958 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.40.50.140 | Mainly Beta | Beta Barrel | OB fold (Dihydrolipoamide Acetyltransferase, E2P) | Nucleic acid-binding proteins | CATH (4.3.0) |
A | 3.40.50.150 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Vaccinia Virus protein VP39 | CATH (4.3.0) |
A | 2.40.50.1070 | Mainly Beta | Beta Barrel | OB fold (Dihydrolipoamide Acetyltransferase, E2P) | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF05958 | tRNA (Uracil-5-)-methyltransferase (tRNA_U5-meth_tr) | tRNA (Uracil-5-)-methyltransferase | - | Family | |
PF21579 | tRNA (uracil(54)-C(5))-methyltransferase, TRAM domain (PabTrmU54_TRAM_dom) | tRNA (uracil(54)-C(5))-methyltransferase, TRAM domain | This domain is found at the N-terminal end of tRNA (uracil(54)-C(5))- methyltransferase from Pyrococcus abyssi (PabTrmU54), which catalyses the formation of 5-methyl-uridine at position 54 (m5U54) in tRNA. This domain, a TRAM domain, adopts a five-st ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR010280 | (Uracil-5)-methyltransferase family | Family | |
IPR048845 | tRNA (uracil(54)-C(5))/23S rRNA (uracil(747)-C(5))-methyltransferase, TRAM domain | Domain | |
IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Homologous Superfamily | |
IPR030391 | RNA methyltransferase TrmA, conserved site | Conserved Site | |
IPR012340 | Nucleic acid-binding, OB-fold | Homologous Superfamily | |
IPR030390 | RNA methyltransferase TrmA, active site | Active Site |