Annotations: 2VQM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Arginase/deacetylase-like	8087563	3000260	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hist_deacetyl	e2vqmA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: Arginase/deacetylase	F: Hist_deacetyl	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.800.20	Alpha Beta	3-Layer(aba) Sandwich	Arginase	Chain A	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	HISTONE DEACETYLASE 4	histone deacetylase binding protein binding binding enzyme binding deacetylase activity protein lysine deacetylase activity catalytic activity, acting on a protein hydrolase activity catalytic activity aminoacyltransferase activity ubiquitin-like protein transferase activity acyltransferase activity SUMO transferase activity transferase activity histone deacetylase binding protein binding binding enzyme binding deacetylase activity protein lysine deacetylase activity catalytic activity, acting on a protein hydrolase activity catalytic activity aminoacyltransferase activity ubiquitin-like protein transferase activity acyltransferase activity SUMO transferase activity transferase activity molecular adaptor activity histone deacetylase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides histone modifying activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds identical protein binding cation binding ion binding potassium ion binding alkali metal ion binding metal ion binding small molecule binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transition metal ion binding zinc ion binding	peptidyl-lysine deacetylation organonitrogen compound metabolic process peptidyl-lysine modification primary metabolic process macromolecule deacylation protein deacetylation protein deacylation organic substance metabolic process macromolecule modification peptidyl-amino acid modification metabolic process protein metabolic process macromolecule metabolic process protein modification process peptidyl-lysine deacetylation organonitrogen compound metabolic process peptidyl-lysine modification primary metabolic process macromolecule deacylation protein deacetylation protein deacylation organic substance metabolic process macromolecule modification peptidyl-amino acid modification metabolic process protein metabolic process macromolecule metabolic process protein modification process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of primary metabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process negative regulation of nucleotide metabolic process regulation of small molecule metabolic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process purine ribonucleotide catabolic process negative regulation of carbohydrate metabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process pyruvate metabolic process cellular metabolic process negative regulation of metabolic process negative regulation of purine nucleotide catabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process regulation of phosphorus metabolic process monocarboxylic acid metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process negative regulation of nucleotide catabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process organic cyclic compound catabolic process purine-containing compound metabolic process ADP metabolic process negative regulation of phosphorus metabolic process purine ribonucleoside diphosphate metabolic process cellular process organic substance catabolic process purine ribonucleoside diphosphate catabolic process ribonucleotide catabolic process regulation of cellular process negative regulation of small molecule metabolic process negative regulation of glycolytic process negative regulation of biological process negative regulation of ATP metabolic process negative regulation of cellular metabolic process nucleobase-containing compound metabolic process glycolytic process pyridine-containing compound metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process regulation of biological process regulation of cellular metabolic process nucleotide metabolic process organic cyclic compound metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process regulation of metabolic process catabolic process purine nucleotide metabolic process ribonucleotide metabolic process negative regulation of cellular process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process negative regulation of catabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process biological regulation ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process organophosphate metabolic process positive regulation of DNA-binding transcription factor activity cellular biosynthetic process RNA metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription multicellular organismal process immune system process B cell activation cell activation lymphocyte activation leukocyte activation protein sumoylation post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal developmental process multicellular organism development anatomical structure development nervous system development system development negative regulation of RNA biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process regulation of muscle adaptation system process response to stimulus regulation of system process regulation of muscle system process muscle system process response to muscle inactivity response to stimulus involved in regulation of muscle adaptation muscle adaptation response to denervation involved in regulation of muscle adaptation regulation of response to stimulus response to muscle inactivity involved in regulation of muscle adaptation response to inactivity regulation of multicellular organismal process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process cellular response to stimulus response to organic substance biological process involved in interspecies interaction between organisms signaling response to cytokine cytokine-mediated signaling pathway response to biotic stimulus cell communication interferon-mediated signaling pathway cellular response to type I interferon response to stress innate immune response cellular response to cytokine stimulus cellular response to organic substance signal transduction response to external biotic stimulus cell surface receptor signaling pathway immune response response to other organism defense response defense response to symbiont response to external stimulus cellular response to chemical stimulus response to chemical defense response to other organism type I interferon-mediated signaling pathway response to type I interferon regulation of protein sumoylation regulation of protein modification process positive regulation of protein metabolic process positive regulation of post-translational protein modification positive regulation of protein modification process regulation of protein modification by small protein conjugation or removal positive regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process positive regulation of protein sumoylation cellular developmental process hemopoiesis cell development mononuclear cell differentiation lymphocyte differentiation B cell differentiation cell differentiation leukocyte differentiation negative regulation of DNA-binding transcription factor activity negative regulation of molecular function response to interleukin-1 protein-DNA complex organization cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis protein-containing complex organization epigenetic regulation of gene expression negative regulation of gene expression negative regulation of gene expression, epigenetic regulation of developmental process negative regulation of muscle cell differentiation regulation of cell differentiation regulation of striated muscle cell differentiation muscle cell differentiation myotube differentiation muscle structure development negative regulation of myotube differentiation regulation of myotube differentiation negative regulation of cell differentiation negative regulation of developmental process negative regulation of striated muscle cell differentiation regulation of muscle cell differentiation striated muscle cell differentiation cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation negative regulation of transcription by competitive promoter binding inflammatory response regulation of protein binding regulation of binding muscle hypertrophy striated muscle adaptation striated muscle hypertrophy cardiac muscle adaptation cardiac muscle hypertrophy cardiac muscle hypertrophy in response to stress muscle hypertrophy in response to stress	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol protein-containing complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle catalytic complex nuclear protein-containing complex histone deacetylase complex transcription regulator complex transcription repressor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000286	Histone deacetylase family	Family
A	IPR023801	Histone deacetylase domain	Domain
A	IPR046949	Histone deacetylase 4/5/7/9	Family
A	IPR024643	Histone deacetylase, glutamine rich N-terminal domain	Domain
A	IPR037138	Histone deacetylase domain superfamily	Homologous Superfamily
A	IPR023696	Ureohydrolase domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P56524	2q37 microdeletion syndrome brachydactyly intellectual disability malignant mesothelioma urinary bladder cancer cocaine abuse contact dermatitis Familial Primary Pulmonary Hypertension cocaine dependence lung cancer medulloblastoma osteosarcoma primary cutaneous T-cell lymphoma chronic obstructive pulmonary disease schizophrenia 2q37 microdeletion syndrome brachydactyly intellectual disability malignant mesothelioma urinary bladder cancer cocaine abuse contact dermatitis Familial Primary Pulmonary Hypertension cocaine dependence lung cancer medulloblastoma osteosarcoma primary cutaneous T-cell lymphoma chronic obstructive pulmonary disease schizophrenia facioscapulohumeral muscular dystrophy glioblastoma invasive ductal breast carcinoma malignant ependymoma amyotrophic lateral sclerosis ovarian cancer brachydactyly type E1 subependymal giant cell astrocytoma urinary bladder neoplasm idiopathic pulmonary arterial hypertension large cell medulloblastoma malignant glioma mature T-cell and NK-cell non-Hodgkin lymphoma myopathy atypical teratoid rhabdoid tumor plasma cell myeloma psoriasis tuberculosis gastric carcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.