2VMC

Structure of the complex of discoidin II from Dictyostelium discoideum with N-acetyl-galactosamine

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00754	e2vmcA2	A: beta sandwiches	X: jelly-roll	H: Galactose-binding domain-like (From Topology)	T: Galactose-binding domain-like	F: PF00754	ECOD (1.6)
A	PF09458	e2vmcA1	A: beta sandwiches	X: Agglutinin HPA-like	H: Agglutinin HPA-like (From Topology)	T: Agglutinin HPA-like	F: PF09458	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
A	2.60.40.2080	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00754	F5/8 type C domain (F5_F8_type_C)	F5/8 type C domain	This domain is also known as the discoidin (DS) domain family [1].	Domain
A	PF09458	H-type lectin domain (H_lectin)	H-type lectin domain	The H-type lectin domain is a unit of six beta chains, combined into a homo-hexamer. It is involved in self/non-self recognition of cells, through binding with carbohydrates [1]. It is sometimes found in association with the F5_F8_type_C domain Pfam: ...	The H-type lectin domain is a unit of six beta chains, combined into a homo-hexamer. It is involved in self/non-self recognition of cells, through binding with carbohydrates [1]. It is sometimes found in association with the F5_F8_type_C domain Pfam:PF00754.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DISCOIDIN-2	binding carbohydrate binding N-acetylgalactosamine binding carbohydrate derivative binding galactoside binding polysaccharide binding oligosaccharide binding cation binding ion binding metal ion binding small molecule binding	cellular component organization organelle organization cellular process cellular component organization or biogenesis cytoskeleton organization cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular component organization organelle organization cellular process cellular component organization or biogenesis cytoskeleton organization cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus cell adhesion cell-cell adhesion	membrane-bounded organelle organelle cellular anatomical entity vesicle cell periphery external encapsulating structure cell wall spore wall intracellular anatomical structure cytoplasm cytosol intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle membrane-bounded organelle organelle cellular anatomical entity vesicle cell periphery external encapsulating structure cell wall spore wall intracellular anatomical structure cytoplasm cytosol intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle endocytic vesicle extracellular matrix protein-containing complex protein complex involved in cell adhesion

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A	IPR037221	H-type lectin domain superfamily	Homologous Superfamily
A	IPR019019	H-type lectin domain	Domain
A	IPR000421	Coagulation factor 5/8 C-terminal domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.