Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AHTH_AsnC-typee2vbzA1 A: alpha arraysX: HTHH: HTHT: wingedF: HTH_AsnC-typeECOD (1.6)
AAsnC_trans_rege2vbzA2 A: a+b two layersX: Alpha-beta plaitsH: Dimeric alpha+beta barrel (From Topology)T: Dimeric alpha+beta barrelF: AsnC_trans_regECOD (1.6)
BHTH_AsnC-typee2vbzB1 A: alpha arraysX: HTHH: HTHT: wingedF: HTH_AsnC-typeECOD (1.6)
BAsnC_trans_rege2vbzB2 A: a+b two layersX: Alpha-beta plaitsH: Dimeric alpha+beta barrel (From Topology)T: Dimeric alpha+beta barrelF: AsnC_trans_regECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF01037Lrp/AsnC ligand binding domain (AsnC_trans_reg)Lrp/AsnC ligand binding domainThe l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to ...The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold [2]. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Domain
A, B
PF13412Winged helix-turn-helix DNA-binding (HTH_24)Winged helix-turn-helix DNA-binding- Domain