2UZC

Structure of human PDLIM5 in complex with the C-terminal peptide of human alpha-actinin-1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2uzca1	All beta proteins	PDZ domain-like	PDZ domain-like	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2uzca2	Artifacts	Tags	Tags	Tags	C-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2uzcc1	All beta proteins	PDZ domain-like	PDZ domain-like	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2uzcc3	Artifacts	Tags	Tags	Tags	C-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2uzcc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2uzcd1	All beta proteins	PDZ domain-like	PDZ domain-like	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2uzcd3	Artifacts	Tags	Tags	Tags	C-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2uzcd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d2uzce1	All beta proteins	PDZ domain-like	PDZ domain-like	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d2uzce2	Artifacts	Tags	Tags	Tags	C-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2uzcb_	All beta proteins	PDZ domain-like	PDZ domain-like	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PDZ domain	8062343	4001790	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PDZ domain-like	8062344	3000388	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	PDZ domain-like	8062344	3000388	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PDZ domain-like	8062344	3000388	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PDZ domain-like	8062344	3000388	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PDZ domain-like	8062344	3000388	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PDZ	e2uzcA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)
C	PDZ	e2uzcC1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)
D	PDZ	e2uzcD1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)
E	PDZ	e2uzcE1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)
B	PDZ	e2uzcB1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
C	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
D	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
E	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
B	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	PDZ AND LIM DOMAIN 5	cytoskeletal protein binding protein binding binding alpha-actinin binding actinin binding muscle alpha-actinin binding cell adhesion molecule binding cadherin binding involved in cell-cell adhesion cadherin binding cell adhesion mediator activity cell-cell adhesion mediator activity actin binding kinase binding protein kinase C binding cytoskeletal protein binding protein binding binding alpha-actinin binding actinin binding muscle alpha-actinin binding cell adhesion molecule binding cadherin binding involved in cell-cell adhesion cadherin binding cell adhesion mediator activity cell-cell adhesion mediator activity actin binding kinase binding protein kinase C binding enzyme binding protein kinase binding cation binding ion binding metal ion binding small molecule binding	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development regulation of cellular process cell projection organization neuron projection development cell projection morphogenesis neuron differentiation neuron projection morphogenesis developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development regulation of cellular process cell projection organization neuron projection development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation regulation of synapse structure or activity dendritic spine morphogenesis synapse organization regulation of biological quality dendritic spine development regulation of biological process dendritic spine organization postsynapse organization regulation of cell projection organization regulation of postsynapse organization nervous system development generation of neurons regulation of neuron projection development regulation of cellular component organization regulation of developmental process cellular developmental process plasma membrane bounded cell projection morphogenesis cell development cell morphogenesis cellular component organization neurogenesis dendrite development cellular component organization or biogenesis regulation of anatomical structure morphogenesis plasma membrane bounded cell projection organization biological regulation dendrite morphogenesis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis regulation of synapse organization cell junction organization neuron development regulation of dendritic spine morphogenesis cellular process neuron projection organization regulation of plasma membrane bounded cell projection organization organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization muscle structure development system process cardiac muscle cell development developmental growth organ growth muscle cell differentiation cell growth striated muscle tissue development muscle cell development cardiac muscle hypertrophy cardiac cell development muscle tissue development cardiac muscle tissue growth muscle hypertrophy heart growth developmental cell growth cardiac muscle tissue development physiological muscle hypertrophy growth cardiac muscle cell differentiation striated muscle hypertrophy tissue development muscle system process cardiocyte differentiation cell growth involved in cardiac muscle cell development physiological cardiac muscle hypertrophy striated muscle cell differentiation cellular component biogenesis cellular component assembly cell junction assembly regulation of synapse assembly regulation of cellular component biogenesis regulation of cell junction assembly synapse assembly	membrane cellular anatomical entity intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer membrane cellular anatomical entity intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cytoskeleton actin cytoskeleton cytosol presynapse synapse cell junction cell-cell junction adherens junction anchoring junction actin filament bundle actomyosin stress fiber contractile actin filament bundle postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse polymeric cytoskeletal fiber protein-containing complex actin filament filamentous actin cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR001781	Zinc finger, LIM-type	Domain
A, B, C, D, E	IPR036034	PDZ superfamily	Homologous Superfamily
A, B, C, D, E	IPR001478	PDZ domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E	Pharos: Q96HC4	medulloblastoma myopathy osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease adenoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor rheumatoid arthritis breast cancer subependymal giant cell astrocytoma dermatomyositis glioblastoma major depressive disorder malignant mesothelioma medulloblastoma myopathy osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease adenoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor rheumatoid arthritis breast cancer subependymal giant cell astrocytoma dermatomyositis glioblastoma major depressive disorder malignant mesothelioma myocardial infarction non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma amyotrophic lateral sclerosis prostate carcinoma Becker muscular dystrophy schizophrenia Chronic schizophrenia Down syndrome tuberculosis hereditary spastic paraplegia malignant ependymoma malignant pancreatic neoplasm myocardial ischemia oligodendroglioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer astrocytic tumor psoriasis bipolar disorder spina bifida coronary artery disease drug-induced liver injury large cell medulloblastoma malignant glioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.