Annotations: 2UV0

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth E]	Autoind_bind	e2uv0E1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Autoind_bind	ECOD (1.6)
B [auth F]	Autoind_bind	e2uv0F1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Autoind_bind	ECOD (1.6)
C [auth G]	Autoind_bind	e2uv0G1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Autoind_bind	ECOD (1.6)
D [auth H]	Autoind_bind	e2uv0H1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Autoind_bind	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth E]	3.30.450.80	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Transcription factor LuxR-like, autoinducer-binding domain	CATH (4.3.0)
B [auth F]	3.30.450.80	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Transcription factor LuxR-like, autoinducer-binding domain	CATH (4.3.0)
C [auth G]	3.30.450.80	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Transcription factor LuxR-like, autoinducer-binding domain	CATH (4.3.0)
D [auth H]	3.30.450.80	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Transcription factor LuxR-like, autoinducer-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth E], B [auth F], C [auth G], D [auth H]	PF03472	Autoinducer binding domain (Autoind_bind)	Autoinducer binding domain	This domain is found a a large family of transcriptional regulators. This domain specifically binds to autoinducer molecules (N-Acyl homoserine lactones, chlorolactone and rosmarinic acid) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 20 ...	This domain is found a a large family of transcriptional regulators. This domain specifically binds to autoinducer molecules (N-Acyl homoserine lactones, chlorolactone and rosmarinic acid) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E], B [auth F], C [auth G], D [auth H]	TRANSCRIPTIONAL ACTIVATOR PROTEIN LASR	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity	catabolic process carbohydrate derivative metabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process protein metabolic process organonitrogen compound catabolic process carbohydrate derivative catabolic process regulation of biological process glycoprotein catabolic process organonitrogen compound metabolic process regulation of protein metabolic process elastin catabolic process biological regulation catabolic process carbohydrate derivative metabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process protein metabolic process organonitrogen compound catabolic process carbohydrate derivative catabolic process regulation of biological process glycoprotein catabolic process organonitrogen compound metabolic process regulation of protein metabolic process elastin catabolic process biological regulation primary metabolic process regulation of elastin catabolic process protein catabolic process regulation of macromolecule metabolic process regulation of catabolic process glycoprotein metabolic process elastin metabolic process regulation of glycoprotein metabolic process metabolic process macromolecule metabolic process organic substance catabolic process regulation of metabolic process regulation of protein catabolic process regulation of cellular process cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process response to stimulus signaling quorum sensing cell-cell signaling detection of cell density detection of biotic stimulus response to biotic stimulus cell communication detection of stimulus positive regulation of glycoprotein metabolic process positive regulation of protein metabolic process organonitrogen compound biosynthetic process positive regulation of elastin biosynthetic process regulation of glycoprotein biosynthetic process positive regulation of glycoprotein biosynthetic process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process regulation of elastin biosynthetic process elastin biosynthetic process	protein-containing complex protein-DNA complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth E], B [auth F], C [auth G], D [auth H]	IPR000792	Transcription regulator LuxR, C-terminal	Domain
A [auth E], B [auth F], C [auth G], D [auth H]	IPR036693	Transcription factor LuxR-like, autoinducer-binding domain superfamily	Homologous Superfamily
A [auth E], B [auth F], C [auth G], D [auth H]	IPR016032	Signal transduction response regulator, C-terminal effector	Homologous Superfamily
A [auth E], B [auth F], C [auth G], D [auth H]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A [auth E], B [auth F], C [auth G], D [auth H]	IPR005143	Transcription factor LuxR-like, autoinducer-binding domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.