2REY

Crystal structure of the PDZ domain of human dishevelled 2 (homologous to Drosophila dsh)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2reya1	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	Segment polarity protein dishevelled homolog Dvl-2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2reya2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00595	e2reyA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02377	Dishevelled specific domain (Dishevelled)	Dishevelled specific domain	-	Family
A	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Segment polarity protein dishevelled homolog DVL-2	small GTPase binding protein binding binding enzyme binding GTPase binding signaling receptor binding G protein-coupled receptor binding frizzled binding protein-macromolecule adaptor activity molecular adaptor activity identical protein binding protein domain specific binding kinase binding protein kinase binding	developmental process multicellular organism development multicellular organismal process segmentation anatomical structure development pattern specification process regionalization segment specification heart development animal organ development circulatory system development system development protein localization localization developmental process multicellular organism development multicellular organismal process segmentation anatomical structure development pattern specification process regionalization segment specification heart development animal organ development circulatory system development system development protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway biological regulation cell communication signal transduction Wnt signaling pathway embryonic epithelial tube formation tube formation epithelial tube formation tube morphogenesis primary neural tube formation establishment of tissue polarity animal organ morphogenesis non-canonical Wnt signaling pathway epithelium development establishment of planar polarity regulation of animal organ morphogenesis planar cell polarity pathway involved in neural tube closure embryonic morphogenesis nervous system development tissue development neural tube closure neural tube formation tube closure regulation of developmental process chordate embryonic development Wnt signaling pathway, planar cell polarity pathway embryo development embryo development ending in birth or egg hatching establishment of planar polarity of embryonic epithelium morphogenesis of a polarized epithelium regulation of establishment of planar polarity involved in neural tube closure epithelial tube morphogenesis regulation of anatomical structure morphogenesis morphogenesis of embryonic epithelium neural tube development tube development morphogenesis of an epithelium establishment of planar polarity involved in neural tube closure regulation of establishment of planar polarity anatomical structure morphogenesis tissue morphogenesis anatomical structure formation involved in morphogenesis positive regulation of DNA-binding transcription factor activity cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette positive regulation of cellular process regulation of signaling positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication positive regulation of signaling neural plate development convergent extension involved in gastrulation convergent extension involved in organogenesis morphogenesis of an epithelial sheet gastrulation convergent extension involved in neural plate elongation neural plate elongation convergent extension neural plate morphogenesis positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation positive regulation of MAP kinase activity protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of JUN kinase activity positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of protein modification process protein metabolic process positive regulation of protein kinase activity organonitrogen compound metabolic process positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of JUN kinase activity regulation of phosphorylation regulation of cellular component organization positive regulation of cellular component organization cellular developmental process regulation of neuron projection arborization cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis regulation of cell morphogenesis cellular component organization positive regulation of developmental process neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation positive regulation of cell projection organization cellular component organization or biogenesis plasma membrane bounded cell projection organization regulation of cell projection organization positive regulation of neuron projection arborization generation of neurons neuron projection arborization neuron development positive regulation of macromolecule biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process heart morphogenesis embryonic heart tube development embryonic heart tube morphogenesis heart looping determination of bilateral symmetry embryonic organ development determination of left/right symmetry specification of symmetry embryonic organ morphogenesis determination of heart left/right asymmetry left/right pattern formation regulation of cytoskeleton organization regulation of actin filament-based process actin cytoskeleton organization regulation of organelle organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cytoskeleton organization ear morphogenesis ear development sensory organ development sensory organ morphogenesis inner ear development cochlea development inner ear morphogenesis cochlea morphogenesis cell population proliferation regulation of cell population proliferation outflow tract morphogenesis	apical part of cell cellular anatomical entity intracellular anatomical structure cytoplasm cytosol inclusion body aggresome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm apical part of cell cellular anatomical entity intracellular anatomical structure cytoplasm cytosol inclusion body aggresome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasmic vesicle intracellular vesicle vesicle clathrin-coated endocytic vesicle clathrin-coated vesicle coated vesicle endocytic vesicle cell periphery plasma membrane membrane lateral plasma membrane nuclear body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000591	DEP domain	Domain
A	IPR008339	Dishevelled family	Family
A	IPR024580	Dishevelled C-terminal	Domain
A	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A	IPR015506	Dishevelled-related protein	Family
A	IPR038207	DIX domain superfamily	Homologous Superfamily
A	IPR003351	Dishevelled protein domain	Domain
A	IPR008341	Dishevelled-2	Family
A	IPR001158	DIX domain	Domain
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR001478	PDZ domain	Domain
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O14641	malignant mesothelioma osteosarcoma vascular disease medulloblastoma ovarian cancer oligodendroglioma psoriasis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.