Annotations: 2R05

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13949	e2r05A2	A: alpha duplicates or obligate multimers	X: Alix V domain (From Topology)	H: Alix V domain (From Topology)	T: Alix V domain	F: PF13949	ECOD (1.6)
A	PF03097	e2r05A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF03097	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.280	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	alix/aip1 like domains	CATH (4.3.0)
A	1.20.120.560	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	alix/aip1 in complex with the ypdl late domain	CATH (4.3.0)
A	1.20.140.50	Mainly Alpha	Up-down Bundle	Butyryl-CoA Dehydrogenase, subunit A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF08705	Gag protein p6 (Gag_p6)	Gag protein p6	HIV protein p6 contains two late-budding domains (L domains) which are short sequence motifs essential for viral particle release. p6 interacts with the endosomal sorting complex and represents a docking site for several cellular and binding factors ...	HIV protein p6 contains two late-budding domains (L domains) which are short sequence motifs essential for viral particle release. p6 interacts with the endosomal sorting complex and represents a docking site for several cellular and binding factors [1]. The PTAP motif interacts with the cellular budding factor TSG101 [1]. This domain is also found in some chimpanzee immunodeficiency virus (SIV-cpz) proteins.	Domain
A	PF13949	ALIX V-shaped domain binding to HIV (ALIX_LYPXL_bnd)	ALIX V-shaped domain binding to HIV	The binding of the LYPxL motif of late HIV p6Gag and EIAV p9Gag to this domain is necessary for viral budding.This domain is generally central between an N-terminal Bro1 domain, Pfam:PF03097 and a C-terminal proline-rich domain. The retroviruses thus ...	The binding of the LYPxL motif of late HIV p6Gag and EIAV p9Gag to this domain is necessary for viral budding.This domain is generally central between an N-terminal Bro1 domain, Pfam:PF03097 and a C-terminal proline-rich domain. The retroviruses thus used this domain to hijack the ESCRT system of the cell.	Domain
A	PF03097	BRO1-like domain (BRO1)	BRO1-like domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	p6-Gag	structural molecule activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding RNA binding organic cyclic compound binding nucleic acid binding	virion assembly viral process viral budding viral budding via host ESCRT complex viral life cycle	host intracellular membrane-bounded organelle host cellular component host intracellular part host multivesicular body cellular anatomical entity host cell cytoplasm part host intracellular organelle host cell cytoplasm host cell part host cell late endosome host cell endosome host intracellular region membrane virion component host intracellular membrane-bounded organelle host cellular component host intracellular part host multivesicular body cellular anatomical entity host cell cytoplasm part host intracellular organelle host cell cytoplasm host cell part host cell late endosome host cell endosome host intracellular region membrane virion component virion membrane host cell nucleus host cell plasma membrane host cell membrane viral nucleocapsid viral capsid
A	Programmed cell death 6-interacting protein	proteinase activated receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding identical protein binding protein homodimerization activity protein dimerization activity calcium-dependent protein binding	mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cellular process cytokinesis cell division cell cycle mitotic cell cycle cell cycle process organelle assembly multivesicular body assembly vesicle organization cellular component organization cellular component biogenesis mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cellular process cytokinesis cell division cell cycle mitotic cell cycle cell cycle process organelle assembly multivesicular body assembly vesicle organization cellular component organization cellular component biogenesis organelle organization cellular component assembly multivesicular body organization endosome organization cellular component organization or biogenesis endomembrane system organization protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization apoptotic process cell death programmed cell death regulation of biological process microtubule organizing center organization regulation of cellular process regulation of cellular component organization regulation of centrosome cycle regulation of cell cycle process microtubule cytoskeleton organization regulation of microtubule-based process biological regulation centrosome duplication centrosome cycle regulation of centrosome duplication microtubule-based process regulation of cell cycle cytoskeleton organization membrane organization mitotic cytokinetic process midbody abscission cytokinetic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity maintenance of cell polarity maintenance of epithelial cell apical/basal polarity maintenance of apical/basal cell polarity establishment or maintenance of apical/basal cell polarity establishment or maintenance of cell polarity virion assembly viral process viral budding viral budding via host ESCRT complex viral life cycle bicellular tight junction assembly tight junction organization apical junction assembly cell junction organization cell junction assembly tight junction assembly cell-cell junction assembly cell-cell junction organization multivesicular body sorting pathway vesicle-mediated transport cellular catabolic process macroautophagy cellular metabolic process autophagy process utilizing autophagic mechanism exosomal secretion establishment of organelle localization regulation of localization positive regulation of biological process positive regulation of secretion by cell positive regulation of exosomal secretion positive regulation of exocytosis secretion by cell regulation of secretion by cell positive regulation of secretion organelle localization establishment of localization in cell positive regulation of cellular process vesicle localization positive regulation of cellular component biogenesis secretion regulation of transport regulation of exosomal secretion establishment of vesicle localization export from cell regulation of cellular component biogenesis regulation of vesicle-mediated transport extracellular exosome biogenesis regulation of secretion exocytosis positive regulation of transport extracellular vesicle biogenesis regulation of exocytosis regulation of extracellular exosome assembly regulation of organelle organization regulation of organelle assembly extracellular exosome assembly assembly of actomyosin apparatus involved in cytokinesis actin cytoskeleton organization actomyosin structure organization cortical cytoskeleton organization actomyosin contractile ring assembly cortical actin cytoskeleton organization actin filament-based process actomyosin contractile ring organization protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization positive regulation of extracellular exosome assembly positive regulation of organelle organization positive regulation of cellular component organization positive regulation of organelle assembly regulation of membrane permeability regulation of biological quality	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton actomyosin non-membrane-bounded organelle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle centrosome microtubule organizing center microtubule cytoskeleton cytosol endoplasmic reticulum exit site endoplasmic reticulum endomembrane system cell periphery immunological synapse plasma membrane endosome cell-cell junction apical junction complex bicellular tight junction tight junction Flemming body midbody

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR000071	Immunodeficiency lentiviral matrix, N-terminal	Domain
B	IPR045345	Retroviral nucleocapsid Gag protein p24, C-terminal domain	Domain
B	IPR036875	Zinc finger, CCHC-type superfamily	Homologous Superfamily
B	IPR001878	Zinc finger, CCHC-type	Domain
B	IPR008919	Retrovirus capsid, N-terminal	Homologous Superfamily
B	IPR010999	Retroviral matrix protein	Homologous Superfamily
B	IPR012344	Matrix protein, lentiviral and alpha-retroviral, N-terminal	Homologous Superfamily
B	IPR014817	Gag protein p6	Domain
B	IPR008916	Retrovirus capsid, C-terminal	Homologous Superfamily
A	IPR004328	BRO1 domain	Domain
A	IPR025304	ALIX V-shaped domain	Domain
A	IPR038499	BRO1 domain superfamily	Homologous Superfamily
A	IPR045251	Vacuolar protein-sorting protein Bro1-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8WUM4	astrocytic tumor IgA glomerulonephritis myopathy osteoarthritis ovarian cancer subependymal giant cell astrocytoma attention deficit hyperactivity disorder, inattentive type lymphoplasmacytic lymphoma non-small cell lung carcinoma osteoarthritis susceptibility 1 pancreatic intraductal papillary-mucinous neoplasm ulcerative colitis glioblastoma malignant ependymoma oligodendroglioma astrocytic tumor IgA glomerulonephritis myopathy osteoarthritis ovarian cancer subependymal giant cell astrocytoma attention deficit hyperactivity disorder, inattentive type lymphoplasmacytic lymphoma non-small cell lung carcinoma osteoarthritis susceptibility 1 pancreatic intraductal papillary-mucinous neoplasm ulcerative colitis glioblastoma malignant ependymoma oligodendroglioma Osteoarthrosis Deformans Pick disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.