2QZJ

Crystal structure of a two-component response regulator from Clostridium difficile

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2qzjb_	Alpha and beta proteins (a/b)	Flavodoxin-like	CheY-like	automated matches	automated matches	(Clostridioides difficile 630 ) [TaxId: 272563 ],	SCOPe (2.08)
E	d2qzje_	Alpha and beta proteins (a/b)	Flavodoxin-like	CheY-like	automated matches	automated matches	(Clostridioides difficile 630 ) [TaxId: 272563 ],	SCOPe (2.08)
A	d2qzja_	Alpha and beta proteins (a/b)	Flavodoxin-like	CheY-like	automated matches	automated matches	(Clostridioides difficile 630 ) [TaxId: 272563 ],	SCOPe (2.08)
C	d2qzjc_	Alpha and beta proteins (a/b)	Flavodoxin-like	CheY-like	automated matches	automated matches	(Clostridioides difficile 630 ) [TaxId: 272563 ],	SCOPe (2.08)
D	d2qzjd_	Alpha and beta proteins (a/b)	Flavodoxin-like	CheY-like	automated matches	automated matches	(Clostridioides difficile 630 ) [TaxId: 272563 ],	SCOPe (2.08)
F	d2qzjf_	Alpha and beta proteins (a/b)	Flavodoxin-like	CheY-like	automated matches	automated matches	(Clostridioides difficile 630 ) [TaxId: 272563 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	CheY-like	8074345	3001156	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	CheY-like	8074345	3001156	SCOP2B (2022-06-29)
A	SCOP2 Family	CheY-related	8074344	4003632	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	CheY-like	8074345	3001156	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	CheY-like	8074345	3001156	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	CheY-like	8074345	3001156	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	CheY-like	8074345	3001156	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00072	e2qzjB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: PF00072	ECOD (1.6)
E	PF00072	e2qzjE1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: PF00072	ECOD (1.6)
A	PF00072	e2qzjA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: PF00072	ECOD (1.6)
C	PF00072	e2qzjC1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: PF00072	ECOD (1.6)
D	PF00072	e2qzjD1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: PF00072	ECOD (1.6)
F	PF00072	e2qzjF1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: PF00072	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)
E	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)
A	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)
C	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)
D	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)
F	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00072	Response regulator receiver domain (Response_reg)	Response regulator receiver domain	This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Two-component response regulator	DNA binding binding organic cyclic compound binding nucleic acid binding	cellular response to stimulus regulation of biological process phosphorelay signal transduction system regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication cellular process signal transduction cellular biosynthetic process RNA metabolic process regulation of primary metabolic process cellular response to stimulus regulation of biological process phosphorelay signal transduction system regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication cellular process signal transduction cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR039420	Transcriptional regulatory protein WalR-like	Family
A, B, C, D, E A, B, C, D, E, F	IPR001867	OmpR/PhoB-type DNA-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011006	CheY-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR001789	Signal transduction response regulator, receiver domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR016032	Signal transduction response regulator, C-terminal effector	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.