2QVH

Crystal structure of O-succinylbenzoate synthase complexed with O-succinyl benzoate (OSB)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PRK02901	e2qvhA3	A: a+b two layers	X: Enolase-N/ribosomal protein	H: Enolase N-terminal domain-like (From Topology)	T: Enolase N-terminal domain-like	F: PRK02901	ECOD (1.6)
A	MR_MLE_C_1	e2qvhA2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: MR_MLE_C_1	ECOD (1.6)
B	PRK02901	e2qvhB2	A: a+b two layers	X: Enolase-N/ribosomal protein	H: Enolase N-terminal domain-like (From Topology)	T: Enolase N-terminal domain-like	F: PRK02901	ECOD (1.6)
B	MR_MLE_C_1	e2qvhB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: MR_MLE_C_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.390.10	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
A	3.20.20.120	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Enolase-like C-terminal domain	CATH (4.3.0)
B	3.30.390.10	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
B	3.20.20.120	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Enolase-like C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF18374	Enolase N-terminal domain-like (Enolase_like_N)	Enolase N-terminal domain-like	This is the N-terminal domain found in o-succinylbenzoate synthase (OSBS) enzymes (EC:4.2.1.113). Like other members of the enolase superfamily, OSBS enzymes are composed of a C-terminal catalytic (beta/alpha)7beta-barrel domain Pfam:PF00113 and an N ...	This is the N-terminal domain found in o-succinylbenzoate synthase (OSBS) enzymes (EC:4.2.1.113). Like other members of the enolase superfamily, OSBS enzymes are composed of a C-terminal catalytic (beta/alpha)7beta-barrel domain Pfam:PF00113 and an N-terminal capping domain with an alpha+beta fold that is found in the enolase superfamily [1]. This domain is different from other enolase super family N-terminal domains such as Pfam:PF03952. This actino-bacterial N-terminal domain lacks the prototypical first two helices of the enolase capping domains. Structural analysis of T. fusca OSBS reveals that this is compensated for with an extra helix appended to the C-terminus [2].	Domain
A, B	PF13378	Enolase C-terminal domain-like (MR_MLE_C)	Enolase C-terminal domain-like	This domain appears at the C-terminus of many of the proteins that carry the MR_MLE_N Pfam:PF02746 domain. EC:4.2.1.40.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	O-succinylbenzoate-CoA synthase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding hydro-lyase activity lyase activity catalytic activity O-succinylbenzoate synthase activity carbon-oxygen lyase activity	catabolic process organic substance metabolic process metabolic process amino acid metabolic process primary metabolic process amino acid catabolic process organic substance catabolic process small molecule biosynthetic process cellular biosynthetic process cellular metabolic process cellular ketone metabolic process biosynthetic process menaquinone metabolic process organic substance biosynthetic process catabolic process organic substance metabolic process metabolic process amino acid metabolic process primary metabolic process amino acid catabolic process organic substance catabolic process small molecule biosynthetic process cellular biosynthetic process cellular metabolic process cellular ketone metabolic process biosynthetic process menaquinone metabolic process organic substance biosynthetic process small molecule metabolic process cellular process menaquinone biosynthetic process ketone biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR010196	o-Succinylbenzoate synthase, MenC type1	Family
A, B	IPR029065	Enolase C-terminal domain-like	Domain
A, B	IPR018110	Mandelate racemase/muconate lactonizing enzyme, conserved site	Conserved Site
A, B	IPR013342	Mandelate racemase/muconate lactonizing enzyme, C-terminal	Domain
A, B	IPR041338	OSBS, enolase-like N-terminal domain	Domain
A, B	IPR036849	Enolase-like, C-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.