2QUB

Crystal structure of extracellular lipase LipA from Serratia marcescens

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth E]	PF00353	e2qubE3	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Serralysin-like metalloprotease-C (From Topology)	T: Serralysin-like metalloprotease-C	F: PF00353	ECOD (1.6)
C [auth E]	F_UNCLASSIFIED	e2qubE5	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
F [auth K]	PF00353	e2qubK1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Serralysin-like metalloprotease-C (From Topology)	T: Serralysin-like metalloprotease-C	F: PF00353	ECOD (1.6)
F [auth K]	F_UNCLASSIFIED	e2qubK2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00353	e2qubA3	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Serralysin-like metalloprotease-C (From Topology)	T: Serralysin-like metalloprotease-C	F: PF00353	ECOD (1.6)
A	F_UNCLASSIFIED	e2qubA5	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth C]	PF00353	e2qubC3	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Serralysin-like metalloprotease-C (From Topology)	T: Serralysin-like metalloprotease-C	F: PF00353	ECOD (1.6)
B [auth C]	F_UNCLASSIFIED	e2qubC5	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth G]	PF00353	e2qubG3	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Serralysin-like metalloprotease-C (From Topology)	T: Serralysin-like metalloprotease-C	F: PF00353	ECOD (1.6)
D [auth G]	F_UNCLASSIFIED	e2qubG5	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth I]	PF00353	e2qubI3	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Serralysin-like metalloprotease-C (From Topology)	T: Serralysin-like metalloprotease-C	F: PF00353	ECOD (1.6)
E [auth I]	F_UNCLASSIFIED	e2qubI5	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth E]	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
F [auth K]	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
B [auth C]	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
D [auth G]	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
E [auth I]	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C], C [auth E], D [auth G], E [auth I], A, B [auth C], C [auth E], D [auth G], E [auth I], F [auth K]	PF00353	RTX calcium-binding nonapeptide repeat (4 copies) (HemolysinCabind)	RTX calcium-binding nonapeptide repeat (4 copies)	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], C [auth E], D [auth G], E [auth I], A, B [auth C], C [auth E], D [auth G], E [auth I], F [auth K]	Extracellular lipase	hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity triglyceride lipase activity hydrolase activity catalytic activity lipase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C], C [auth E], D [auth G], E [auth I], A, B [auth C], C [auth E], D [auth G], E [auth I], F [auth K]	IPR001343	RTX calcium-binding nonapeptide repeat	Repeat
A, B [auth C], C [auth E], D [auth G], E [auth I], A, B [auth C], C [auth E], D [auth G], E [auth I], F [auth K]	IPR011049	Serralysin-like metalloprotease, C-terminal	Homologous Superfamily
A, B [auth C], C [auth E], D [auth G], E [auth I], A, B [auth C], C [auth E], D [auth G], E [auth I], F [auth K]	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.