2QSC
Crystal structure analysis of anti-HIV-1 V3-Fab F425-B4e8 in complex with a V3-peptide
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth L] | d2qscl1 | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | V set domains (antibody variable domain-like) | Immunoglobulin light chain kappa variable domain, VL-kappa | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A [auth L] | d2qscl2 | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | C1 set domains (antibody constant domain-like) | Immunoglobulin light chain kappa constant domain, CL-kappa | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth L] | PF07654 | e2qscL2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
A [auth L] | PF07686 | e2qscL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
B [auth H] | PF07654 | e2qscH2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
B [auth H] | PF07686 | e2qscH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A [auth L] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
B [auth H] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
A [auth L] | F425-B4e8 (B4e8) mAb, anti-gp120 [HIV-1], neutralizing | L-KAPPA | Homo sapiens (human) | IGKV1-33*01, IGKV1D-33*01, IGKJ4*01, IGKJ4*02, IGKC*01 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | FAB-GAMMA-2_KAPPA | IMGT (202416-0) |
B [auth H] | F425-B4e8 (B4e8) mAb, anti-gp120 [HIV-1], neutralizing | VH-CH1 | Homo sapiens (human) | IGHV3-64*01, IGHJ3*01, IGHG2*01, IGHG2*06, IGHG2*05, IGHG2*03 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-2_KAPPA | IMGT (202416-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
A [auth L] | Light Chain | IGKV1 | Kappa | envelope glycoprotein gp120 | SAbDab (2024-04-26) |
B [auth H] | Heavy Chain | IGHV3 | - | envelope glycoprotein gp120 | SAbDab (2024-04-26) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
C [auth P] | PF00516 | Envelope glycoprotein GP120 (GP120) | Envelope glycoprotein GP120 | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
C [auth P] | IPR000777 | Human immunodeficiency virus 1, envelope glycoprotein Gp120 | Domain |
C [auth P] | IPR036377 | Gp120 core superfamily | Homologous Superfamily |
C [auth P] | IPR000328 | Retroviral envelope protein GP41-like | Domain |
C [auth P] | IPR037527 | Envelope glycoprotein Gp160 | Family |