2QRW

Crystal structure of Mycobacterium tuberculosis trHbO WG8F mutant

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2qrwa_	All alpha proteins	Globin-like	Globin-like	Truncated hemoglobin	Protozoan/bacterial hemoglobin	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
C	d2qrwc_	All alpha proteins	Globin-like	Globin-like	Truncated hemoglobin	Protozoan/bacterial hemoglobin	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
D	d2qrwd_	All alpha proteins	Globin-like	Globin-like	Truncated hemoglobin	Protozoan/bacterial hemoglobin	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
E	d2qrwe_	All alpha proteins	Globin-like	Globin-like	Truncated hemoglobin	Protozoan/bacterial hemoglobin	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
F	d2qrwf_	All alpha proteins	Globin-like	Globin-like	Truncated hemoglobin	Protozoan/bacterial hemoglobin	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
G	d2qrwg_	All alpha proteins	Globin-like	Globin-like	Truncated hemoglobin	Protozoan/bacterial hemoglobin	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
H	d2qrwh_	All alpha proteins	Globin-like	Globin-like	Truncated hemoglobin	Protozoan/bacterial hemoglobin	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
I	d2qrwi_	All alpha proteins	Globin-like	Globin-like	Truncated hemoglobin	Protozoan/bacterial hemoglobin	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
J	d2qrwj_	All alpha proteins	Globin-like	Globin-like	Truncated hemoglobin	Protozoan/bacterial hemoglobin	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
K	d2qrwk_	All alpha proteins	Globin-like	Globin-like	Truncated hemoglobin	Protozoan/bacterial hemoglobin	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
L	d2qrwl_	All alpha proteins	Globin-like	Globin-like	Truncated hemoglobin	Protozoan/bacterial hemoglobin	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
B	d2qrwb_	All alpha proteins	Globin-like	Globin-like	Truncated hemoglobin	Protozoan/bacterial hemoglobin	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Globin-like	8033299	3000554	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Globin-like	8033299	3000554	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Globin-like	8033299	3000554	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Globin-like	8033299	3000554	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Globin-like	8033299	3000554	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Globin-like	8033299	3000554	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Globin-like	8033299	3000554	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Globin-like	8033299	3000554	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Globin-like	8033299	3000554	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Globin-like	8033299	3000554	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Globin-like	8033299	3000554	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Globin-like	8033299	3000554	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01152	e2qrwA1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: PF01152	ECOD (1.6)
C	PF01152	e2qrwC1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: PF01152	ECOD (1.6)
D	PF01152	e2qrwD1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: PF01152	ECOD (1.6)
E	PF01152	e2qrwE1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: PF01152	ECOD (1.6)
F	PF01152	e2qrwF1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: PF01152	ECOD (1.6)
G	PF01152	e2qrwG1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: PF01152	ECOD (1.6)
H	PF01152	e2qrwH1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: PF01152	ECOD (1.6)
I	PF01152	e2qrwI1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: PF01152	ECOD (1.6)
J	PF01152	e2qrwJ1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: PF01152	ECOD (1.6)
K	PF01152	e2qrwK1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: PF01152	ECOD (1.6)
L	PF01152	e2qrwL1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: PF01152	ECOD (1.6)
B	PF01152	e2qrwB1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: PF01152	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
C	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
D	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
E	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
F	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
G	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
H	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
I	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
J	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
K	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
L	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
B	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF01152	Bacterial-like globin (Bac_globin)	Bacterial-like globin	This family of heme binding proteins are found mainly in bacteria. However they can also be found in some protozoa and plants as well.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Hemoglobin-like protein HbO	oxygen binding binding small molecule binding oxygen carrier activity molecular carrier activity organic cyclic compound binding tetrapyrrole binding heme binding cation binding ion binding metal ion binding	oxygen transport localization transport gas transport establishment of localization	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR019795	Globin, bacterial-like, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR001486	Truncated hemoglobin	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR044203	Group 2 truncated hemoglobin GlbO/Two-on-two hemoglobin-3-like	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR009050	Globin-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR012292	Globin/Protoglobin	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	OPM	Monotopic/peripheral	All alpha monotopic/peripheral	Globin-like	Bacterial globin

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.