2QKH

Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2B Superfamily	FnI-like domain	8086311	3000979	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	HRM	e2qkhA1	A: few secondary structure elements	X: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	H: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	T: Hormone receptor domain (HRM, Pfam 02793)	F: HRM	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth A]	4.10.1240.10	Few Secondary Structures	Irregular	Hormone receptor fold	GPCR, family 2, extracellular hormone receptor domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B]	PF00123	Peptide hormone (Hormone_2)	Peptide hormone	-	Family
B [auth A]	PF02793	Hormone receptor domain (HRM)	Hormone receptor domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	Glucose-dependent insulinotropic polypeptide	protein binding binding signaling receptor binding G protein-coupled receptor binding glucagon receptor binding gastric inhibitory polypeptide receptor binding hormone activity molecular function activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	response to acid chemical response to organic substance response to stimulus response to chemical response to amino acid response to xenobiotic stimulus response to stress response to wounding response to axon injury adult locomotory behavior behavior multicellular organismal process adult behavior locomotory behavior response to acid chemical response to organic substance response to stimulus response to chemical response to amino acid response to xenobiotic stimulus response to stress response to wounding response to axon injury adult locomotory behavior behavior multicellular organismal process adult behavior locomotory behavior response to hormone response to endogenous stimulus response to organonitrogen compound response to peptide hormone response to oxygen-containing compound response to nitrogen compound response to selenium ion response to inorganic substance exploration behavior multi-multicellular organism process reproductive process female pregnancy multi-organism reproductive process chemical homeostasis homeostatic process triglyceride homeostasis acylglycerol homeostasis lipid homeostasis cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus cAMP-mediated signaling regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction positive regulation of cAMP-mediated signaling regulation of response to stimulus regulation of cell communication cellular process regulation of cAMP-mediated signaling positive regulation of signaling system process learning or memory nervous system process cognition memory developmental process multicellular organism development digestive system development anatomical structure development system development response to hexose response to monosaccharide response to carbohydrate response to glucose gastric inhibitory peptide signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway pancreas development endocrine system development animal organ development endocrine pancreas development protein localization regulation of localization establishment of protein localization nitrogen compound transport localization cellular macromolecule localization regulation of biological quality regulation of peptide hormone secretion regulation of hormone levels organic substance transport establishment of protein localization to extracellular region protein secretion establishment of localization regulation of protein secretion regulation of secretion cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion transport hormone secretion protein localization to extracellular region peptide secretion secretion by cell regulation of secretion by cell amide transport signal release secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization cell-cell signaling export from cell regulation of protein transport peptide transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport insulin secretion hexose transmembrane transport carbohydrate transport positive regulation of transmembrane transport glucose transmembrane transport positive regulation of glucose transmembrane transport transmembrane transport regulation of glucose transmembrane transport regulation of transmembrane transport positive regulation of transport monosaccharide transmembrane transport carbohydrate transmembrane transport oxoacid metabolic process cellular biosynthetic process regulation of lipid metabolic process lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process regulation of primary metabolic process organic substance metabolic process cellular ketone metabolic process regulation of small molecule metabolic process organic substance biosynthetic process small molecule metabolic process regulation of biosynthetic process fatty acid metabolic process regulation of cellular ketone metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process primary metabolic process regulation of cellular metabolic process fatty acid biosynthetic process regulation of cellular biosynthetic process biosynthetic process regulation of fatty acid biosynthetic process cellular lipid metabolic process regulation of fatty acid metabolic process metabolic process regulation of lipid biosynthetic process monocarboxylic acid metabolic process regulation of metabolic process lipid metabolic process sensory perception sensory perception of pain response to lipid positive regulation of establishment of protein localization positive regulation of insulin secretion positive regulation of peptide hormone secretion positive regulation of protein localization positive regulation of secretion by cell positive regulation of protein transport positive regulation of hormone secretion positive regulation of secretion positive regulation of peptide secretion positive regulation of protein secretion response to organic cyclic compound response to pH response to abiotic stimulus response to acidic pH modulation of chemical synaptic transmission long-term synaptic potentiation synaptic signaling regulation of synaptic plasticity trans-synaptic signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling response to nutrient levels response to starvation	membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm extracellular region membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm extracellular region vesicle lumen intracellular vesicle cytoplasmic vesicle lumen secretory granule lumen cytoplasmic vesicle secretory granule secretory vesicle vesicle somatodendritic compartment cell body neuronal cell body extracellular space
B [auth A]	Glucose-dependent insulinotropic polypeptide receptor	amide binding glucagon family peptide binding binding peptide hormone binding hormone binding molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity gastric inhibitory peptide receptor activity peptide receptor activity G protein-coupled peptide receptor activity	response to stimulus response to stress response to wounding response to axon injury positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality response to metal ion response to chemical response to calcium ion response to inorganic substance cellular response to stimulus positive regulation of cell communication regulation of cellular process response to stimulus response to stress response to wounding response to axon injury positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality response to metal ion response to chemical response to calcium ion response to inorganic substance cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus cAMP-mediated signaling regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of intracellular signal transduction positive regulation of cAMP-mediated signaling regulation of response to stimulus regulation of cell communication cellular process regulation of cAMP-mediated signaling positive regulation of signaling adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway negative adaptation of signaling pathway negative regulation of signaling negative regulation of biological process desensitization of G protein-coupled receptor signaling pathway negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication negative regulation of cellular process regulation of G protein-coupled receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction adaptation of signaling pathway cellular metabolic process metabolic process generation of precursor metabolites and energy response to hexose response to organic substance response to monosaccharide response to carbohydrate response to glucose response to oxygen-containing compound gastric inhibitory peptide signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway developmental process multicellular organism development multicellular organismal process pancreas development endocrine system development anatomical structure development animal organ development endocrine pancreas development system development protein localization regulation of localization establishment of protein localization nitrogen compound transport localization cellular macromolecule localization regulation of peptide hormone secretion regulation of hormone levels organic substance transport establishment of protein localization to extracellular region protein secretion establishment of localization regulation of protein secretion regulation of secretion cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion transport hormone secretion protein localization to extracellular region peptide secretion secretion by cell regulation of secretion by cell amide transport signal release secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization cell-cell signaling export from cell regulation of protein transport peptide transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport insulin secretion cell surface receptor signaling pathway positive regulation of adenylate cyclase activity positive regulation of cyclase activity regulation of catalytic activity positive regulation of catalytic activity positive regulation of molecular function regulation of molecular function regulation of lyase activity activation of adenylate cyclase activity regulation of adenylate cyclase activity regulation of cyclase activity positive regulation of lyase activity response to lipid response to fatty acid response to nutrient levels response to nutrient positive regulation of establishment of protein localization positive regulation of insulin secretion positive regulation of peptide hormone secretion positive regulation of protein localization positive regulation of secretion by cell positive regulation of protein transport positive regulation of hormone secretion positive regulation of secretion positive regulation of peptide secretion positive regulation of protein secretion positive regulation of transport	membrane cellular anatomical entity cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR039078	Gastric inhibitory polypeptide	Family
A [auth B]	IPR000532	Glucagon/GIP/secretin/VIP	Domain
B [auth A]	IPR017983	GPCR, family 2, secretin-like, conserved site	Conserved Site
B [auth A]	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily	Homologous Superfamily
B [auth A]	IPR000832	GPCR, family 2, secretin-like	Family
B [auth A]	IPR017981	GPCR, family 2-like, 7TM	Domain
B [auth A]	IPR001879	GPCR, family 2, extracellular hormone receptor domain	Domain
B [auth A]	IPR001749	GPCR, family 2, gastric inhibitory polypeptide receptor	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B]	Pharos: P09681	Anorexia hyperglycemia type 2 diabetes mellitus hypoglycemia heart disease obesity disorder
B [auth A]	Pharos: P48546	Body Weight non-small cell lung carcinoma heart disease type 2 diabetes mellitus lung carcinoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth B], B [auth A]	OPM	Peptides	Alpha-helical peptides	Peptide hormones	Glucagon family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.