2QFI

Structure of the zinc transporter YiiP

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2qfia1	Alpha and beta proteins (a+b)	Alpha-lytic protease prodomain-like	Cation efflux protein cytoplasmic domain-like	Cation efflux protein cytoplasmic domain-like	Ferrous-iron efflux pump FieF (YiiP)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d2qfia2	Membrane and cell surface proteins and peptides	Cation efflux protein transmembrane domain-like	Cation efflux protein transmembrane domain-like	Cation efflux protein transmembrane domain-like	Ferrous-iron efflux pump FieF	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d2qfib1	Alpha and beta proteins (a+b)	Alpha-lytic protease prodomain-like	Cation efflux protein cytoplasmic domain-like	Cation efflux protein cytoplasmic domain-like	Ferrous-iron efflux pump FieF (YiiP)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d2qfib2	Membrane and cell surface proteins and peptides	Cation efflux protein transmembrane domain-like	Cation efflux protein transmembrane domain-like	Cation efflux protein transmembrane domain-like	Ferrous-iron efflux pump FieF	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Cation efflux protein transmembrane domain-like	8023529	4002765	SCOP2 (2022-06-29)
A	SCOP2 Family	Cation efflux protein cytoplasmic domain-like	8023528	4001860	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Cation efflux protein transmembrane domain-like	8035909	3001720	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Cation efflux protein cytoplasmic domain-like	8035908	3000470	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Cation efflux protein cytoplasmic domain-like	8035908	3000470	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cation efflux protein transmembrane domain-like	8035909	3001720	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01545	e2qfiA1	A: alpha bundles	X: Cation efflux protein transmembrane domain-like (From Topology)	H: Cation efflux protein transmembrane domain-like (From Topology)	T: Cation efflux protein transmembrane domain-like	F: PF01545	ECOD (1.6)
A	PF16916	e2qfiA2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Cation efflux protein cytoplasmic domain-like (From Topology)	T: Cation efflux protein cytoplasmic domain-like	F: PF16916	ECOD (1.6)
B	PF01545	e2qfiB1	A: alpha bundles	X: Cation efflux protein transmembrane domain-like (From Topology)	H: Cation efflux protein transmembrane domain-like (From Topology)	T: Cation efflux protein transmembrane domain-like	F: PF01545	ECOD (1.6)
B	PF16916	e2qfiB2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Cation efflux protein cytoplasmic domain-like (From Topology)	T: Cation efflux protein cytoplasmic domain-like	F: PF16916	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1510.10	Mainly Alpha	Up-down Bundle	Alpha-lytic protease prodomain-like	Cation efflux protein transmembrane domain	CATH (4.3.0)
A	3.30.70.1350	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Cation efflux protein, cytoplasmic domain	CATH (4.3.0)
B	1.20.1510.10	Mainly Alpha	Up-down Bundle	Alpha-lytic protease prodomain-like	Cation efflux protein transmembrane domain	CATH (4.3.0)
B	3.30.70.1350	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Cation efflux protein, cytoplasmic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF16916	Dimerisation domain of Zinc Transporter (ZT_dimer)	Dimerisation domain of Zinc Transporter	ZT_dimer is the dimerisation region of the whole molecule of zinc transporters since the full-length members form a homodimer during activity. The domain lies within the cytoplasm and exhibits an overall structural similarity with the copper metalloc ...	ZT_dimer is the dimerisation region of the whole molecule of zinc transporters since the full-length members form a homodimer during activity. The domain lies within the cytoplasm and exhibits an overall structural similarity with the copper metallochaperone Hah1 UniProtKB:O00244, exhibiting an open alpha-beta domain with two alpha helices (H1 and H2) aligned on one side and a three-stranded mixed beta-sheet (S1 to S3) on the other side. The N-terminal part of the members is the Cation_efflux family, Pfam:PF01545 [1].	Domain
A, B	PF01545	Cation efflux family (Cation_efflux)	Cation efflux family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Ferrous-iron efflux pump fieF	monoatomic cation transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transition metal ion transmembrane transporter activity metal ion transmembrane transporter activity cadmium ion transmembrane transporter activity transmembrane transporter activity iron ion transmembrane transporter activity ferrous iron transmembrane transporter activity zinc ion transmembrane transporter activity zinc efflux active transmembrane transporter activity efflux transmembrane transporter activity monoatomic cation transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transition metal ion transmembrane transporter activity metal ion transmembrane transporter activity cadmium ion transmembrane transporter activity transmembrane transporter activity iron ion transmembrane transporter activity ferrous iron transmembrane transporter activity zinc ion transmembrane transporter activity zinc efflux active transmembrane transporter activity efflux transmembrane transporter activity monoatomic cation efflux transmembrane transporter activity secondary active transmembrane transporter activity active monoatomic ion transmembrane transporter activity zinc efflux transmembrane transporter activity active transmembrane transporter activity antiporter activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	localization transport iron ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport cadmium ion transport zinc ion transport inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process localization transport iron ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport cadmium ion transport zinc ion transport inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis intracellular zinc ion homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR027470	Cation efflux protein, cytoplasmic domain	Domain
A, B	IPR002524	Cation efflux protein	Family
A, B	IPR023783	Cation efflux pump FieF	Family
A, B	IPR036837	Cation efflux protein, cytoplasmic domain superfamily	Homologous Superfamily
A, B	IPR027469	Cation efflux transmembrane domain superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Cation diffusion facilitator	Bacterial zinc transporters

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.