Annotations: 2QDQ

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01608	I/LWEQ domain (I_LWEQ)	I/LWEQ domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Talin-1	binding phospholipid binding lipid binding phosphatidylinositol binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding LIM domain binding protein domain specific binding vinculin binding cell adhesion molecule binding integrin binding binding phospholipid binding lipid binding phosphatidylinositol binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding LIM domain binding protein domain specific binding vinculin binding cell adhesion molecule binding integrin binding signaling receptor binding structural constituent of cytoskeleton structural molecule activity modified amino acid binding phosphatidylserine binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process integrin activation cellular component organization or biogenesis cellular response to stimulus regulation of biological process integrin-mediated signaling pathway regulation of cellular process cell surface receptor signaling pathway response to stimulus cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process integrin activation cellular component organization or biogenesis cellular response to stimulus regulation of biological process integrin-mediated signaling pathway regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell communication signal transduction cell junction organization cell junction assembly cell-substrate junction assembly cell-substrate junction organization organelle organization actin cytoskeleton organization cortical actin cytoskeleton organization cortical cytoskeleton organization actin filament-based process cytoskeleton organization cell adhesion cell-cell adhesion	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane cell surface intracellular anatomical structure cytoplasm cell-cell junction adherens junction intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000299	FERM domain	Domain
A, B	IPR014352	FERM/acyl-CoA-binding protein superfamily	Homologous Superfamily
A, B	IPR019748	FERM central domain	Domain
A, B	IPR015009	Vinculin-binding site-containing domain	Domain
A, B	IPR032425	Talin, N-terminal F0 domain	Domain
A, B	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B	IPR035964	I/LWEQ domain superfamily	Homologous Superfamily
A, B	IPR015224	Talin, central	Domain
A, B	IPR019749	Band 4.1 domain	Domain
A, B	IPR035963	FERM superfamily, second domain	Homologous Superfamily
A, B	IPR036476	Talin, central domain superfamily	Homologous Superfamily
A, B	IPR036723	Alpha-catenin/vinculin-like superfamily	Homologous Superfamily
A, B	IPR002558	I/LWEQ domain	Domain
A, B	IPR019747	FERM conserved site	Conserved Site
A, B	IPR049108	Talin, R4 domain	Domain
A, B	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A, B	IPR037438	Talin-1/2, rod-segment	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.