2Q7M

Crystal structure of human FLAP with MK-591

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2q7ma1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Arachidonate 5-lipoxygenase-activating protein, FLAP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2q7mb1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Arachidonate 5-lipoxygenase-activating protein, FLAP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2q7mc1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Arachidonate 5-lipoxygenase-activating protein, FLAP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d2q7me1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Arachidonate 5-lipoxygenase-activating protein, FLAP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d2q7mf1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Arachidonate 5-lipoxygenase-activating protein, FLAP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2q7md1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Arachidonate 5-lipoxygenase-activating protein, FLAP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MAPEG domain-like	8035275	3001687	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	MAPEG domain-like	8035275	3001687	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	MAPEG domain-like	8035275	3001687	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	MAPEG domain-like	8035275	3001687	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	MAPEG domain-like	8035275	3001687	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	MAPEG domain-like	8035275	3001687	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01124	e2q7mA1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: PF01124	ECOD (1.6)
B	PF01124	e2q7mB1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: PF01124	ECOD (1.6)
C	PF01124	e2q7mC1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: PF01124	ECOD (1.6)
E	PF01124	e2q7mE1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: PF01124	ECOD (1.6)
F	PF01124	e2q7mF1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: PF01124	ECOD (1.6)
D	PF01124	e2q7mD1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: PF01124	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF01124	MAPEG family (MAPEG)	MAPEG family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Arachidonate 5-lipoxygenase-activating protein	enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein-containing complex binding binding peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor glutathione peroxidase activity catalytic activity glutathione transferase activity transferase activity enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein-containing complex binding binding peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor glutathione peroxidase activity catalytic activity glutathione transferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups arachidonate 5-lipoxygenase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity, acting on single donors with incorporation of molecular oxygen dioxygenase activity fatty acid binding icosanoid binding organic acid binding arachidonic acid binding long-chain fatty acid binding icosatetraenoic acid binding ion binding anion binding lipid binding carboxylic acid binding small molecule binding monocarboxylic acid binding protein binding enzyme binding carbon-sulfur lyase activity leukotriene-C4 synthase activity lyase activity identical protein binding	icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process small molecule biosynthetic process cellular biosynthetic process cellular metabolic process leukotriene biosynthetic process carboxylic acid metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process icosanoid biosynthetic process organic substance biosynthetic process icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process small molecule biosynthetic process cellular biosynthetic process cellular metabolic process leukotriene biosynthetic process carboxylic acid metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process icosanoid biosynthetic process organic substance biosynthetic process small molecule metabolic process metabolic process cellular process fatty acid metabolic process primary metabolic process cellular lipid metabolic process lipoxygenase pathway monocarboxylic acid metabolic process lipid metabolic process regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus defense response biological regulation positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of acute inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus response to stress regulation of response to stress positive regulation of defense response regulation of acute inflammatory response inflammatory response acute inflammatory response protein-containing complex organization protein trimerization cellular component organization cellular component biogenesis cellular component assembly protein homotrimerization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis arachidonic acid metabolite production involved in inflammatory response production of molecular mediator involved in inflammatory response multicellular organismal process leukotriene production involved in inflammatory response cellular response to stimulus cellular response to inorganic substance cellular response to metal ion response to inorganic substance cellular response to chemical stimulus response to metal ion response to chemical cellular response to calcium ion response to calcium ion	membrane cellular anatomical entity membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane organelle membrane endoplasmic reticulum membrane cellular anatomical entity membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane organelle membrane endoplasmic reticulum cytoplasm organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR001129	Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein	Family
A, B, C, D, E A, B, C, D, E, F	IPR018295	FLAP/GST2/LTC4S, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR023352	Membrane associated eicosanoid/glutathione metabolism-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR001446	5-lipoxygenase-activating protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: P20292	liver disease atherosclerosis proteinuria cerebral infarction lung adenocarcinoma malignant ependymoma malignant pancreatic neoplasm non-small cell lung carcinoma pilocytic astrocytoma adrenal cortex carcinoma sarcoidosis Atherogenesis tuberculosis cutaneous lupus erythematosus glioblastoma liver disease atherosclerosis proteinuria cerebral infarction lung adenocarcinoma malignant ependymoma malignant pancreatic neoplasm non-small cell lung carcinoma pilocytic astrocytoma adrenal cortex carcinoma sarcoidosis Atherogenesis tuberculosis cutaneous lupus erythematosus glioblastoma invasive ductal breast carcinoma lung cancer malignant glioma medulloblastoma pancreatic ductal adenocarcinoma Sjogren syndrome Down syndrome ulcerative colitis IgA glomerulonephritis lung carcinoma malignant mesothelioma pancreatic intraductal papillary-mucinous carcinoma arteriosclerosis disorder toxic encephalopathy Crohn disease interstitial cystitis large cell medulloblastoma

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E A, B, C, D, E, F	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Membrane-Associated Proteins in Eicosanoid and Glutathione Metabolism (MAPEG)	5-Lipoxygenase-Activating Protein (FLAP) with Bound MK-591 Inhibitor

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.