2Q7D

Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-kinase (ITPK1) in complex with AMPPNP and Mn2+

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Ins134_P3_kin_C	e2q7dB1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: Ins134_P3_kin_C	ECOD (1.6)
B	Ins134_P3_kin_N	e2q7dB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: PreATP-grasp domain	F: Ins134_P3_kin_N	ECOD (1.6)
A	Ins134_P3_kin_C	e2q7dA2	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: Ins134_P3_kin_C	ECOD (1.6)
A	Ins134_P3_kin_N	e2q7dA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: PreATP-grasp domain	F: Ins134_P3_kin_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.11370	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.30.470.20	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)
A	3.40.50.11370	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
A	3.30.470.20	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF17927	Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain (Ins134_P3_kin_N)	Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain	This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphat ...	This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase [1]. This entry represents the N-terminal pre-ATP-grasp domain.	Domain
A, B	PF05770	Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain (Ins134_P3_kin)	Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain	This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphat ...	This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase [1]. This entry represents the ATP-grasp domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Inositol-tetrakisphosphate 1-kinase	inositol tetrakisphosphate kinase activity kinase activity inositol tetrakisphosphate 1-kinase activity transferase activity inositol phosphate kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding inositol tetrakisphosphate kinase activity kinase activity inositol tetrakisphosphate 1-kinase activity transferase activity inositol phosphate kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding inositol tetrakisphosphate 6-kinase activity inositol-3,4,6-trisphosphate 1-kinase activity inositol trisphosphate kinase activity isomerase activity hydrolase activity inositol-1,3,4-trisphosphate 5-kinase activity inositol-1,3,4-trisphosphate 6-kinase activity	multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding polyol metabolic process cellular metabolic process organic hydroxy compound metabolic process multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding polyol metabolic process cellular metabolic process organic hydroxy compound metabolic process alcohol metabolic process inositol phosphate metabolic process organic substance metabolic process organophosphate metabolic process phosphate-containing compound metabolic process inositol trisphosphate metabolic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process phosphorylation necroptotic process programmed necrotic cell death cell death programmed cell death developmental process epithelium development neural tube development tube development chordate embryonic development nervous system development embryo development tissue development multicellular organism development embryo development ending in birth or egg hatching anatomical structure development system development cellular response to stimulus regulation of biological process regulation of cellular process signaling signal transduction cell communication	cell periphery apical part of cell membrane plasma membrane plasma membrane region cellular anatomical entity apical plasma membrane intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR011761	ATP-grasp fold	Domain
A, B	IPR041429	Inositol-tetrakisphosphate 1-kinase, N-terminal	Domain
A, B	IPR008656	Inositol-tetrakisphosphate 1-kinase	Family
A, B	IPR040464	Inositol 1,3,4-trisphosphate 5/6-kinase, ATP-grasp domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q13572	Neoplasm Invasiveness atypical teratoid rhabdoid tumor ductal breast carcinoma in situ malignant ependymoma pancreatic intraductal papillary-mucinous neoplasm breast fibroadenoma glioblastoma malignant glioma osteosarcoma primitive neuroectodermal tumor chronic obstructive pulmonary disease large cell medulloblastoma medulloblastoma ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.