2Q14

Crystal structure of Phosphohydrolase (BT4208) from Bacteroides thetaiotaomicron VPI-5482 at 2.20 A resolution

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	PF01966,PF19276	e2q14D1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF01966,PF19276	ECOD (1.6)
E	PF01966,PF19276	e2q14E1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF01966,PF19276	ECOD (1.6)
F	PF01966,PF19276	e2q14F1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF01966,PF19276	ECOD (1.6)
G	PF01966,PF19276	e2q14G1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF01966,PF19276	ECOD (1.6)
A	PF01966,PF19276	e2q14A1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF01966,PF19276	ECOD (1.6)
B	PF01966,PF19276	e2q14B1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF01966,PF19276	ECOD (1.6)
C	PF01966,PF19276	e2q14C1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF01966,PF19276	ECOD (1.6)
H	PF01966,PF19276	e2q14H1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF01966,PF19276	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	CATH (4.3.0)
D	1.20.1250.30	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
E	1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	CATH (4.3.0)
E	1.20.1250.30	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
F	1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	CATH (4.3.0)
F	1.20.1250.30	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
G	1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	CATH (4.3.0)
G	1.20.1250.30	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
A	1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	CATH (4.3.0)
A	1.20.1250.30	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
B	1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	CATH (4.3.0)
B	1.20.1250.30	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
C	1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	CATH (4.3.0)
C	1.20.1250.30	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
H	1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	CATH (4.3.0)
H	1.20.1250.30	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF19276	HD associated region (HD_assoc_2)	HD associated region	-	Family
A, B, C, D, E A, B, C, D, E, F, G, H	PF01966	HD domain (HD)	HD domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Phosphohydrolase	phosphoric ester hydrolase activity triphosphoric monoester hydrolase activity dGTPase activity hydrolase activity, acting on ester bonds hydrolase activity catalytic activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding	deoxyribonucleotide catabolic process catabolic process nucleoside triphosphate catabolic process purine nucleoside triphosphate catabolic process purine deoxyribonucleoside triphosphate metabolic process carbohydrate derivative metabolic process organophosphate catabolic process dGTP metabolic process nucleoside phosphate catabolic process deoxyribose phosphate catabolic process nucleobase-containing compound metabolic process organic substance metabolic process purine nucleotide metabolic process deoxyribonucleotide metabolic process purine deoxyribonucleoside triphosphate catabolic process deoxyribonucleotide catabolic process catabolic process nucleoside triphosphate catabolic process purine nucleoside triphosphate catabolic process purine deoxyribonucleoside triphosphate metabolic process carbohydrate derivative metabolic process organophosphate catabolic process dGTP metabolic process nucleoside phosphate catabolic process deoxyribose phosphate catabolic process nucleobase-containing compound metabolic process organic substance metabolic process purine nucleotide metabolic process deoxyribonucleotide metabolic process purine deoxyribonucleoside triphosphate catabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process nucleotide catabolic process deoxyribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process purine deoxyribonucleotide catabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process cellular metabolic process 2'-deoxyribonucleotide metabolic process primary metabolic process purine-containing compound catabolic process deoxyribonucleoside triphosphate catabolic process nucleotide metabolic process deoxyribose phosphate metabolic process organic cyclic compound catabolic process purine-containing compound metabolic process nucleobase-containing compound catabolic process organic cyclic compound metabolic process organophosphate metabolic process purine deoxyribonucleotide metabolic process metabolic process cellular process nucleoside triphosphate metabolic process dGTP catabolic process organic substance catabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR003607	HD/PDEase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR045509	HD-associated domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR006674	HD domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.