2PSO

Human StarD13 (DLC2) lipid transfer and protein localization domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2psoa1	Alpha and beta proteins (a+b)	TBP-like	Bet v1-like	STAR domain	Star-related lipid transfer protein 13	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2psob_	Alpha and beta proteins (a+b)	TBP-like	Bet v1-like	STAR domain	Star-related lipid transfer protein 13	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2psoc_	Alpha and beta proteins (a+b)	TBP-like	Bet v1-like	STAR domain	Star-related lipid transfer protein 13	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	STAR domain	8023656	4002052	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Bet v1-like	8036036	3000738	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Bet v1-like	8036036	3000738	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Bet v1-like	8036036	3000738	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	START	e2psoA1	A: a+b two layers	X: TBP-like	H: Bet v1-like (From Topology)	T: Bet v1-like	F: START	ECOD (1.6)
B	START	e2psoB1	A: a+b two layers	X: TBP-like	H: Bet v1-like (From Topology)	T: Bet v1-like	F: START	ECOD (1.6)
C	START	e2psoC1	A: a+b two layers	X: TBP-like	H: Bet v1-like (From Topology)	T: Bet v1-like	F: START	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.530.20	Alpha Beta	2-Layer Sandwich	Alpha-D-Glucose-1,6-Bisphosphate	Chain A, domain 4	CATH (4.3.0)
B	6.10.250.1870	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	3.30.530.20	Alpha Beta	2-Layer Sandwich	Alpha-D-Glucose-1,6-Bisphosphate	Chain A, domain 4	CATH (4.3.0)
C	3.30.530.20	Alpha Beta	2-Layer Sandwich	Alpha-D-Glucose-1,6-Bisphosphate	Chain A, domain 4	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF01852	START domain (START)	START domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	StAR-related lipid transfer protein 13	binding lipid binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity	cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction biological regulation regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction biological regulation regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication cellular process signal transduction multicellular organismal process negative regulation of locomotion regulation of cell motility cell migration involved in sprouting angiogenesis regulation of blood vessel endothelial cell migration endothelial cell migration negative regulation of biological process negative regulation of endothelial cell migration negative regulation of blood vessel endothelial cell migration multicellular organism development tube morphogenesis tissue migration negative regulation of epithelial cell migration anatomical structure development blood vessel endothelial cell migration cell migration negative regulation of cell migration blood vessel development system development developmental process blood vessel morphogenesis regulation of cell migration involved in sprouting angiogenesis vasculature development epithelium migration regulation of locomotion negative regulation of cell motility negative regulation of multicellular organismal process negative regulation of cell migration involved in sprouting angiogenesis angiogenesis ameboidal-type cell migration regulation of cell migration negative regulation of cellular process regulation of endothelial cell migration epithelial cell migration regulation of multicellular organismal process cell motility regulation of epithelial cell migration locomotion tube development sprouting angiogenesis circulatory system development anatomical structure morphogenesis anatomical structure formation involved in morphogenesis epithelium development endothelium development morphogenesis of an endothelium endothelial tube lumen extension endothelial tube morphogenesis morphogenesis of an epithelium tissue development tissue morphogenesis epithelial tube morphogenesis cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization regulation of Rho protein signal transduction Rho protein signal transduction	lipid droplet intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle mitochondrial membrane mitochondrion membrane intracellular membrane-bounded organelle organelle envelope mitochondrial envelope lipid droplet intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle mitochondrial membrane mitochondrion membrane intracellular membrane-bounded organelle organelle envelope mitochondrial envelope cytoplasm organelle membrane cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR000198	Rho GTPase-activating protein domain	Domain
A, B, C	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A, B, C	IPR023393	START-like domain superfamily	Homologous Superfamily
A, B, C	IPR002913	START domain	Domain
A, B, C	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A, B, C	IPR001660	Sterile alpha motif domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q9Y3M8	brain aneurysm Liver Cirrhosis, Experimental invasive ductal breast carcinoma lung cancer medulloblastoma psoriasis ductal breast carcinoma in situ lung carcinoma non-small cell lung carcinoma hydrolethalus syndrome lung adenocarcinoma malignant colon neoplasm pancreatic intraductal papillary-mucinous neoplasm

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C	OPM	Monotopic/peripheral	Alpha + Beta monotopic/peripheral	Bet v1-like	STAR domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.