2PNV

Crystal Structure of the leucine zipper domain of small-conductance Ca2+-activated K+ (SKCa) channel from Rattus norvegicus

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Small conductance calcium-activated potassium channel protein 2	protein binding binding protein domain specific binding cytoskeletal protein binding alpha-actinin binding actinin binding monoatomic cation transmembrane transporter activity calcium-activated cation channel activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity potassium channel activity monoatomic ion-gated channel activity calcium-activated potassium channel activity protein binding binding protein domain specific binding cytoskeletal protein binding alpha-actinin binding actinin binding monoatomic cation transmembrane transporter activity calcium-activated cation channel activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity potassium channel activity monoatomic ion-gated channel activity calcium-activated potassium channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ligand-gated monoatomic cation channel activity metal ion transmembrane transporter activity transmembrane transporter activity small conductance calcium-activated potassium channel activity identical protein binding protein homodimerization activity protein dimerization activity calmodulin binding inward rectifier potassium channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity voltage-gated potassium channel activity	transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport cardiac muscle cell membrane repolarization heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction membrane repolarization signaling atrial cardiac muscle cell to AV node cell signaling regulation of heart contraction membrane repolarization during cardiac muscle cell action potential regulation of system process cell-cell signaling involved in cardiac conduction cardiac muscle contraction striated muscle contraction cell communication circulatory system process membrane repolarization during atrial cardiac muscle cell action potential actin filament-based process regulation of multicellular organismal process regulation of biological quality atrial cardiac muscle cell to AV node cell communication cell communication involved in cardiac conduction blood circulation cardiac muscle cell contraction regulation of biological process atrial cardiac muscle cell action potential biological regulation cell-cell signaling action potential actin filament-based movement muscle contraction muscle system process membrane repolarization during action potential regulation of blood circulation cardiac conduction atrial cardiac muscle cell membrane repolarization cardiac muscle cell action potential actin-mediated cell contraction heart contraction regulation of membrane potential trans-synaptic signaling regulation of signaling regulation of cellular process modulation of chemical synaptic transmission chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of localization regulation of potassium ion transport regulation of transport regulation of monoatomic ion transport positive regulation of biological process positive regulation of potassium ion transport positive regulation of transport positive regulation of monoatomic ion transport regulation of metal ion transport regulation of neuronal synaptic plasticity regulation of synaptic plasticity regulation of monoatomic ion transmembrane transport regulation of potassium ion transmembrane transport regulation of transmembrane transport regulation of monoatomic cation transmembrane transport	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane sarcolemma T-tubule intracellular anatomical structure Z disc cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane sarcolemma T-tubule intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cell surface membrane-bounded organelle endoplasmic reticulum smooth endoplasmic reticulum intracellular membrane-bounded organelle endomembrane system glutamatergic synapse neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection dendrite dendritic tree cell body neuronal cell body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR015449	Potassium channel, calcium-activated, SK	Family
A, B	IPR013099	Potassium channel domain	Domain
A, B	IPR036122	SK, calmodulin-binding domain superfamily	Homologous Superfamily
A, B	IPR004178	Calmodulin-binding domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.