2PNG

Type I rat fatty acid synthase acyl carrier protein (ACP) domain

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad2pnga_ All alpha proteins Acyl carrier protein-like ACP-like Acyl-carrier protein (ACP) Type I fatty acid synthase ACP domain Norway rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyAcyl-carrier protein (ACP)8031529 4000857 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyACP-like8043907 3001805 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APF00550e2pngA1 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: PF00550ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.10.1200.10 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein Chain ACATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00550Phosphopantetheine attachment site (PP-binding)Phosphopantetheine attachment siteA 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes memb ...A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Fatty acid synthase (EC 2.3.1.85)

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR016035Acyl transferase/acyl hydrolase/lysophospholipaseHomologous Superfamily
IPR013217Methyltransferase type 12Domain
IPR020807Polyketide synthase, dehydratase domainDomain
IPR049552Polyketide synthase, dehydratase domain, N-terminalDomain
IPR016036Malonyl-CoA ACP transacylase, ACP-bindingHomologous Superfamily
IPR020806Polyketide synthase, phosphopantetheine-binding domainDomain
IPR032821Polyketide synthase, C-terminal extensionDomain
IPR011032GroES-like superfamilyHomologous Superfamily
IPR009081Phosphopantetheine binding ACP domainDomain
IPR016039Thiolase-likeHomologous Superfamily
IPR001227Acyl transferase domain superfamilyHomologous Superfamily
IPR036291NAD(P)-binding domain superfamilyHomologous Superfamily
IPR018201Beta-ketoacyl synthase, active siteActive Site
IPR001031ThioesteraseDomain
IPR014031Beta-ketoacyl synthase, C-terminalDomain
IPR006162Phosphopantetheine attachment sitePTM
IPR014030Beta-ketoacyl synthase, N-terminalDomain
IPR049391Fatty acid synthase, pseudo-KR domainDomain
IPR020843Polyketide synthase, enoylreductase domainDomain
IPR013968Polyketide synthase, ketoreductase domainDomain
IPR014043Acyl transferaseDomain
IPR020841Polyketide synthase, beta-ketoacyl synthase domainDomain
IPR036736ACP-like superfamilyHomologous Superfamily
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
IPR029058Alpha/Beta hydrolase foldHomologous Superfamily
IPR042104Polyketide synthase, dehydratase domain superfamilyHomologous Superfamily