2PNB

STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2pnba_	Alpha and beta proteins (a+b)	SH2-like	SH2 domain	SH2 domain	Phosphatidylinositol 3-kinase, p85-alpha subunit	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00017	e2pnbA1	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: PF00017	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00017	SH2 domain (SH2)	SH2 domain	-	Domain
A	PF16454	Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain (PI3K_P85_iSH2)	Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain	This domain is found between the two SH2 domains in phosphatidylinositol 3-kinase regulatory subunit P85. It forms a complex with the adaptor-binding domain of phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT N-TERMINAL SH2 DOMAIN	transmembrane receptor protein tyrosine kinase adaptor activity protein tyrosine kinase binding binding signaling receptor binding receptor tyrosine kinase binding enzyme binding protein kinase binding molecular adaptor activity signaling adaptor activity protein binding signaling receptor complex adaptor activity kinase binding protein-macromolecule adaptor activity enzyme regulator activity transmembrane receptor protein tyrosine kinase adaptor activity protein tyrosine kinase binding binding signaling receptor binding receptor tyrosine kinase binding enzyme binding protein kinase binding molecular adaptor activity signaling adaptor activity protein binding signaling receptor complex adaptor activity kinase binding protein-macromolecule adaptor activity enzyme regulator activity molecular function regulator activity 1-phosphatidylinositol-3-kinase regulator activity kinase regulator activity insulin receptor substrate binding insulin receptor binding phosphatidylinositol 3-kinase binding enzyme-substrate adaptor activity phosphatidylinositol 3-kinase regulator activity phosphatidylinositol 3-kinase activator activity ErbB-3 class receptor binding identical protein binding insulin-like growth factor receptor binding	cellular homeostasis chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular response to stimulus regulation of biological process regulation of cellular process cellular homeostasis chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling intracellular signal transduction cell communication intracellular signaling cassette cellular process signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process glycerolipid metabolic process lipid metabolic process positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of protein localization positive regulation of biological process localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of protein localization to plasma membrane establishment of protein localization nitrogen compound transport transport organic substance transport establishment of localization protein transport cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion cell surface receptor signaling pathway insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization import into nucleus establishment of localization in cell regulation of intracellular transport positive regulation of protein localization to nucleus positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus establishment of protein localization to organelle regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport positive regulation of nucleocytoplasmic transport regulation of protein localization to nucleus positive regulation of protein transport regulation of protein import into nucleus protein import into nucleus positive regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of protein transport positive regulation of transport protein localization to organelle RNA metabolic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process RNA processing regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process RNA splicing positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression regulation of RNA splicing macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression positive regulation of gene expression regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of RNA splicing regulation of metabolic process positive regulation of cellular biosynthetic process cellular response to nitrogen compound response to organic substance response to peptide hormone insulin receptor signaling pathway cellular response to endogenous stimulus response to hormone cellular response to organic substance cellular response to hormone stimulus response to endogenous stimulus response to organonitrogen compound response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical response to insulin cellular response to insulin stimulus DNA-templated transcription transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process positive regulation of RNA biosynthetic process hexose transmembrane transport glucose import carbohydrate transport positive regulation of transmembrane transport glucose transmembrane transport regulation of glucose import positive regulation of glucose transmembrane transport transmembrane transport regulation of glucose transmembrane transport regulation of transmembrane transport monosaccharide transmembrane transport positive regulation of glucose import carbohydrate transmembrane transport positive regulation of cell communication positive regulation of signal transduction regulation of cellular response to stress endoplasmic reticulum unfolded protein response regulation of response to endoplasmic reticulum stress regulation of signal transduction positive regulation of response to stimulus regulation of endoplasmic reticulum unfolded protein response positive regulation of response to endoplasmic reticulum stress cellular response to stress response to stress regulation of response to stress positive regulation of endoplasmic reticulum unfolded protein response response to endoplasmic reticulum stress regulation of signaling cellular response to topologically incorrect protein cellular response to unfolded protein response to unfolded protein regulation of response to stimulus response to topologically incorrect protein regulation of cell communication positive regulation of signaling	protein-containing complex catalytic complex membrane phosphatidylinositol 3-kinase complex, class I membrane protein complex cellular anatomical entity transferase complex phosphatidylinositol 3-kinase complex, class IA phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups extrinsic component of membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure protein-containing complex catalytic complex membrane phosphatidylinositol 3-kinase complex, class I membrane protein complex cellular anatomical entity transferase complex phosphatidylinositol 3-kinase complex, class IA phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups extrinsic component of membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036860	SH2 domain superfamily	Homologous Superfamily
A	IPR000980	SH2 domain	Domain
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A	IPR035020	PI3K p85 subunit, C-terminal SH2 domain	Domain
A	IPR035591	Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain	Domain
A	IPR000198	Rho GTPase-activating protein domain	Domain
A	IPR032498	PI3K regulatory subunit p85-related , inter-SH2 domain	Domain
A	IPR001452	SH3 domain	Domain
A	IPR035022	PI3K p85 subunit, N-terminal SH2 domain	Domain
A	IPR044124	PIK3R1, inter-SH2 domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.