Annotations: 2PMY

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13202	e2pmyA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13202	ECOD (1.6)
B	PF13202	e2pmyB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13202	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	RAS and EF-hand domain-containing protein	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding guanyl nucleotide binding nucleotide binding GDP binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding cation binding ion binding binding calcium ion binding metal ion binding small molecule binding guanyl nucleotide binding nucleotide binding GDP binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding GTP binding purine ribonucleoside triphosphate binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity identical protein binding protein binding	localization transport cellular process establishment of localization vesicle-mediated transport	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol perinuclear region of cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001806	Small GTPase	Family
A, B	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, B	IPR005225	Small GTP-binding protein domain	Domain
A, B	IPR002048	EF-hand domain	Domain
A, B	IPR011992	EF-hand domain pair	Homologous Superfamily
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q8IZ41	subependymal giant cell astrocytoma breast carcinoma ductal breast carcinoma in situ invasive ductal breast carcinoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome breast fibroadenoma glioblastoma lung carcinoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer spina bifida subependymal giant cell astrocytoma breast carcinoma ductal breast carcinoma in situ invasive ductal breast carcinoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome breast fibroadenoma glioblastoma lung carcinoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer spina bifida cystic fibrosis interstitial cystitis malignant ependymoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm sarcoidosis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.