2PKP

Crystal structure of 3-isopropylmalate dehydratase (leuD)from Methhanocaldococcus Jannaschii DSM2661 (MJ1271)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2pkpa_	Alpha and beta proteins (a/b)	The 'swivelling' beta/beta/alpha domain	LeuD/IlvD-like	automated matches	automated matches	(Methanocaldococcus jannaschii DSM 2661 ) [TaxId: 243232 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	LeuD-like	8066078	4003492	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	LeuD/IlvD-like	8066079	3000947	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Aconitase_C	e2pkpA1	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Aconitase_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.19.10	Alpha Beta	Alpha-Beta Barrel	Aconitase	domain 4	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00694	Aconitase C-terminal domain (Aconitase_C)	Aconitase C-terminal domain	Members of this family usually also match to Pfam:PF00330. This domain undergoes conformational change in the enzyme mechanism [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Homoaconitase small subunit	hydro-lyase activity homoaconitate hydratase activity lyase activity catalytic activity carbon-oxygen lyase activity maleate hydratase activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity cation binding transition metal ion binding zinc ion binding hydro-lyase activity homoaconitate hydratase activity lyase activity catalytic activity carbon-oxygen lyase activity maleate hydratase activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding aconitate hydratase activity	oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process small molecule metabolic process phosphorus metabolic process coenzyme B biosynthetic process organonitrogen compound metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process small molecule metabolic process phosphorus metabolic process coenzyme B biosynthetic process organonitrogen compound metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process cellular modified amino acid metabolic process biosynthetic process coenzyme B metabolic process cellular modified amino acid biosynthetic process metabolic process cellular process monocarboxylic acid metabolic process	protein-containing complex catalytic complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015928	Aconitase/3-isopropylmalate dehydratase, swivel	Homologous Superfamily
A	IPR000573	Aconitase A/isopropylmalate dehydratase small subunit, swivel domain	Domain
A	IPR033940	3-isopropylmalate dehydratase, swivel domain	Domain
A	IPR011827	Hydrolyase LeuD/HacB/DmdB	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.