2PE4

Structure of Human Hyaluronidase 1, a Hyaluronan Hydrolyzing Enzyme Involved in Tumor Growth and Angiogenesis

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01630	e2pe4A1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF01630	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01630	Hyaluronidase (Glyco_hydro_56)	Hyaluronidase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Hyaluronidase-1	hydrolase activity, acting on glycosyl bonds chondroitin hydrolase activity hexosaminidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity endogalactosaminidase activity catalytic activity UDP-glycosyltransferase activity glycosyltransferase activity transferase activity hyaluronan synthase activity hexosyltransferase activity hyalurononglucosaminidase activity	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development regulation of biological process regulation of growth regulation of cellular process regulation of cellular component organization developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development regulation of biological process regulation of growth regulation of cellular process regulation of cellular component organization positive regulation of biological process biological regulation growth positive regulation of cell growth regulation of cell growth cell growth cellular component organization positive regulation of growth cellular process cellular component organization or biogenesis positive regulation of cellular process organonitrogen compound catabolic process carbohydrate derivative catabolic process catabolic process organonitrogen compound metabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process organic substance metabolic process aminoglycan metabolic process metabolic process macromolecule metabolic process organic substance catabolic process hyaluranon cable assembly positive regulation of cellular component organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis cellular component biogenesis cellular component assembly positive regulation of hyaluranon cable assembly regulation of hyaluranon cable assembly cellular response to endogenous stimulus cellular response to growth factor stimulus cellular response to platelet-derived growth factor stimulus response to stimulus response to endogenous stimulus response to growth factor response to platelet-derived growth factor carbohydrate metabolic process primary metabolic process embryonic skeletal joint development embryonic organ morphogenesis chordate embryonic development embryonic morphogenesis embryo development anatomical structure morphogenesis embryonic skeletal joint morphogenesis embryo development ending in birth or egg hatching embryonic skeletal system development animal organ morphogenesis skeletal system morphogenesis embryonic organ development embryonic skeletal system morphogenesis response to chemical response to antibiotic mucopolysaccharide metabolic process hyaluronan metabolic process negative regulation of biological process negative regulation of cell growth negative regulation of growth negative regulation of cellular process cellular response to stimulus response to pH cellular response to pH response to abiotic stimulus cellular response to abiotic stimulus cellular response to environmental stimulus cell population proliferation positive regulation of cell population proliferation positive regulation of epithelial cell proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation response to fibroblast growth factor cellular response to fibroblast growth factor stimulus carbohydrate derivative biosynthetic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process macromolecule biosynthetic process hyaluronan biosynthetic process biosynthetic process organic substance biosynthetic process aminoglycan biosynthetic process glycosaminoglycan biosynthetic process regulation of cell cycle phase transition cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle regulation of cell cycle cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of cell cycle process positive regulation of cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition cellular catabolic process chondroitin sulfate catabolic process sulfur compound metabolic process protein metabolic process chondroitin sulfate metabolic process chondroitin sulfate proteoglycan metabolic process glycoprotein metabolic process sulfur compound catabolic process proteoglycan metabolic process response to light stimulus cellular response to radiation response to UV response to UV-B cellular response to UV-B cellular response to light stimulus response to radiation cellular response to UV cell adhesion positive regulation of cell adhesion regulation of cell adhesion response to organic substance response to cytokine cellular response to chemical stimulus cellular response to tumor necrosis factor cellular response to cytokine stimulus cellular response to organic substance response to tumor necrosis factor regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process tube morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development regulation of multicellular organismal development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus defense response response to stress inflammatory response response to oxidative stress response to oxygen-containing compound response to reactive oxygen species cellular response to interleukin-1 response to interleukin-1 hyaluronan catabolic process positive regulation of locomotion regulation of cell motility positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration cell migration epithelial cell migration cell motility regulation of epithelial cell migration locomotion epithelium migration regulation of locomotion	membrane-bounded organelle intracellular anatomical structure lytic vacuole membrane-enclosed lumen vacuolar lumen vacuole cellular anatomical entity intracellular membrane-bounded organelle lysosomal lumen intracellular organelle lumen intracellular organelle organelle lumen organelle cytoplasm membrane-bounded organelle intracellular anatomical structure lytic vacuole membrane-enclosed lumen vacuolar lumen vacuole cellular anatomical entity intracellular membrane-bounded organelle lysosomal lumen intracellular organelle lumen intracellular organelle organelle lumen organelle cytoplasm lysosome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasmic vesicle intracellular vesicle hyaluranon cable

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018155	Hyaluronidase	Family
A	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q12794	mucopolysaccharidosis type 9 mucopolysaccharidosis Hyperammonemia lung adenocarcinoma inborn errors of metabolism lysosomal storage disease intellectual disability

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.