2P8Q

Crystal Structure of human Importin beta bound to the Snurportin1 IBB-domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2p8qa_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Armadillo repeat	Importin beta	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2p8qb_	Small proteins	Intrinsically disordered proteins	importin-beta binding (IBB) domain of snurportin-1	importin-beta binding (IBB) domain of snurportin-1	importin-beta binding (IBB) domain of snurportin-1	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8038528	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IBN_N	e2p8qA4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: IBN_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00514	Armadillo/beta-catenin-like repeat (Arm)	Armadillo/beta-catenin-like repeat	-	Repeat
A	PF03810	Importin-beta N-terminal domain (IBN_N)	Importin-beta N-terminal domain	-	Repeat
B	PF11538	Snurportin1 (Snurportin1)	Snurportin1	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Importin beta-1 subunit	small GTPase binding protein binding binding enzyme binding GTPase binding protein domain specific binding Hsp90 protein binding heat shock protein binding RNA binding organic cyclic compound binding nucleic acid binding nuclear localization sequence binding signal sequence binding peptide binding small GTPase binding protein binding binding enzyme binding GTPase binding protein domain specific binding Hsp90 protein binding heat shock protein binding RNA binding organic cyclic compound binding nucleic acid binding nuclear localization sequence binding signal sequence binding peptide binding nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity importin-alpha family protein binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular localization RNA import into nucleus RNA transport nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport nucleic acid transport intracellular transport establishment of localization localization import into nucleus establishment of RNA localization establishment of localization in cell cellular localization RNA import into nucleus RNA transport nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport nucleic acid transport intracellular transport establishment of localization localization import into nucleus establishment of RNA localization establishment of localization in cell macromolecule localization cellular process RNA localization nucleobase-containing compound transport mitotic cell cycle cellular component organization mitotic chromosome movement towards spindle pole chromosome localization organelle localization mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation chromosome movement towards spindle pole cell cycle process mitotic nuclear division organelle fission chromosome organization sister chromatid segregation organelle organization nuclear division mitotic cell cycle process nuclear chromosome segregation microtubule-based movement microtubule-based process establishment of organelle localization mitotic metaphase chromosome alignment metaphase chromosome alignment establishment of chromosome localization microtubule cytoskeleton organization spindle localization establishment of mitotic spindle localization establishment of spindle localization microtubule cytoskeleton organization involved in mitosis cytoskeleton organization protein localization establishment of protein localization protein localization to nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport astral microtubule organization cytoplasmic microtubule organization supramolecular fiber organization spindle organization NLS-bearing protein import into nucleus non-membrane-bounded organelle assembly cellular component biogenesis cellular component assembly organelle assembly spindle assembly mitotic spindle organization mitotic spindle assembly ribosomal protein import into nucleus	intracellular anatomical structure cytoplasmic ribonucleoprotein granule cellular anatomical entity ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule protein-containing complex nucleocytoplasmic transport complex NLS-dependent protein nuclear import complex intracellular anatomical structure cytoplasmic ribonucleoprotein granule cellular anatomical entity ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule protein-containing complex nucleocytoplasmic transport complex NLS-dependent protein nuclear import complex membrane membrane-bounded organelle organelle envelope nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol nuclear protein-containing complex nuclear pore membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular organelle lumen organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen secretory granule secretory vesicle nucleoplasm nuclear lumen organelle subcompartment endoplasmic reticulum subcompartment endoplasmic reticulum endoplasmic reticulum tubular network vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule
B	Snurportin-1	nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity RNA binding binding organic cyclic compound binding nucleic acid binding RNA cap binding	cellular localization RNA import into nucleus RNA transport nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport nucleic acid transport intracellular transport establishment of localization localization import into nucleus establishment of RNA localization establishment of localization in cell cellular localization RNA import into nucleus RNA transport nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport nucleic acid transport intracellular transport establishment of localization localization import into nucleus establishment of RNA localization establishment of localization in cell macromolecule localization cellular process RNA localization nucleobase-containing compound transport snRNA import into nucleus snRNA transport protein localization establishment of protein localization protein localization to nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport	protein-containing complex nucleocytoplasmic transport complex NLS-dependent protein nuclear import complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle protein-containing complex nucleocytoplasmic transport complex NLS-dependent protein nuclear import complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope nuclear pore membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR021133	HEAT, type 2	Repeat
A	IPR000225	Armadillo	Repeat
A	IPR001494	Importin-beta, N-terminal domain	Domain
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR040122	Importin beta family	Family
B	IPR002652	Importin-alpha, importin-beta-binding domain	Domain
B	IPR017336	Snurportin-1	Family
B	IPR047857	Snurportin-1, m3G cap-binding domain	Domain
B	IPR024721	Snurportin-1, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q14974	HIV infectious disease subependymal giant cell astrocytoma astrocytic tumor dental caries Hashimoto thyroiditis large cell medulloblastoma lymphoplasmacytic lymphoma osteosarcoma Pick disease atypical teratoid rhabdoid tumor dermatomyositis HIV Coinfection lung adenocarcinoma malignant glioma ovarian cancer HIV infectious disease subependymal giant cell astrocytoma astrocytic tumor dental caries Hashimoto thyroiditis large cell medulloblastoma lymphoplasmacytic lymphoma osteosarcoma Pick disease atypical teratoid rhabdoid tumor dermatomyositis HIV Coinfection lung adenocarcinoma malignant glioma ovarian cancer psoriasis glioblastoma lung cancer medulloblastoma pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.