2P82

Cysteine protease ATG4A

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2p82a1	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Autophagin-like	Cysteine protease ATG4A	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2p82b_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Autophagin-like	Cysteine protease ATG4A	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2p82c_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Autophagin-like	Cysteine protease ATG4A	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2p82d_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Autophagin-like	Cysteine protease ATG4A	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Autophagin-like	8023070	4002557	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Cysteine proteinases	8035450	3001808	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Cysteine proteinases	8035450	3001808	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cysteine proteinases	8035450	3001808	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cysteine proteinases	8035450	3001808	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Peptidase_C54	e2p82A1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Peptidase_C54	ECOD (1.6)
B	Peptidase_C54	e2p82B1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Peptidase_C54	ECOD (1.6)
C	Peptidase_C54	e2p82C1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Peptidase_C54	ECOD (1.6)
D	Peptidase_C54	e2p82D1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Peptidase_C54	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF03416	Peptidase family C54 (Peptidase_C54)	Peptidase family C54	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Cysteine protease ATG4A	cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity protein-phosphatidylethanolamide deconjugating activity	organic substance metabolic process organonitrogen compound metabolic process macromolecule modification protein delipidation metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process autophagosome assembly catabolic process organelle assembly vacuole organization macroautophagy organic substance metabolic process organonitrogen compound metabolic process macromolecule modification protein delipidation metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process autophagosome assembly catabolic process organelle assembly vacuole organization macroautophagy cellular metabolic process autophagy autophagosome organization cellular component biogenesis cellular component organization cellular catabolic process organelle organization cellular component assembly cellular process cellular component organization or biogenesis process utilizing autophagic mechanism protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization lipid metabolic process proteolysis	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR046792	Peptidase C54, catalytic domain	Domain
A, B, C, D	IPR005078	Peptidase C54	Family
A, B, C, D	IPR046793	Cysteine protease ATG4, F-type LIR motif	Conserved Site
A, B, C, D	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q8WYN0	lung cancer osteosarcoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.