2P6B

Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth A]	d2p6ba_	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	Protein serine/threonine phosphatase	Protein phosphatase-2B (PP-2B, calcineurin A subunit)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth C]	d2p6bc_	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	Protein serine/threonine phosphatase	Protein phosphatase-2B (PP-2B, calcineurin A subunit)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth B]	d2p6bb1	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calcineurin regulatory subunit (B-chain)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth D]	d2p6bd1	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calcineurin regulatory subunit (B-chain)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth B]	SCOP2B Superfamily	EF-hand	8037367	3001983	SCOP2B (2022-06-29)
E [auth D]	SCOP2B Superfamily	EF-hand	8037367	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	Metallophos_2_1	e2p6bA1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
D [auth C]	Metallophos_2_1	e2p6bC1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
C [auth B]	EF-hand_7_10	e2p6bB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_10	ECOD (1.6)
C [auth B]	EF-hand_7_1	e2p6bB2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_1	ECOD (1.6)
E [auth D]	EF-hand_7_10	e2p6bD1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_10	ECOD (1.6)
E [auth D]	EF-hand_7_1	e2p6bD2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth A]	3.60.21.10	Alpha Beta	4-Layer Sandwich	Purple Acid Phosphatase	chain A, domain 2	CATH (4.3.0)
D [auth C]	3.60.21.10	Alpha Beta	4-Layer Sandwich	Purple Acid Phosphatase	chain A, domain 2	CATH (4.3.0)
C [auth B]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
E [auth D]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth A], D [auth C]	PF00149	Calcineurin-like phosphoesterase (Metallophos)	Calcineurin-like phosphoesterase	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or ...	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or yeast MRE11 Swiss:P32829. The most conserved regions in this superfamily centre around the metal chelating residues.	Domain
C [auth B], E [auth D]	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E]	PVIVIT 14-mer Peptide	-	-	-
B [auth A], D [auth C]	Calmodulin-dependent calcineurin A subunit alpha isoform	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity myosin phosphatase activity protein-containing complex binding binding protein binding calmodulin binding amide binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity myosin phosphatase activity protein-containing complex binding binding protein binding calmodulin binding amide binding cyclosporin A binding protein dimerization activity ATPase binding enzyme binding calmodulin-dependent protein phosphatase activity calcium-dependent protein serine/threonine phosphatase activity cation binding ion binding calcium ion binding metal ion binding small molecule binding	calcineurin-NFAT signaling cascade cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette cellular process signal transduction calcineurin-mediated signaling calcineurin-NFAT signaling cascade cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette cellular process signal transduction calcineurin-mediated signaling regulation of signaling negative regulation of signaling negative regulation of biological process multicellular organismal process renal system process system process renal filtration response to metal ion response to chemical response to calcium ion response to inorganic substance developmental process regulation of developmental process animal organ development positive regulation of biological process regulation of kidney development positive regulation of glomerulus development positive regulation of kidney development renal system development positive regulation of developmental process glomerulus development multicellular organism development regulation of glomerulus development anatomical structure development positive regulation of multicellular organismal process regulation of multicellular organismal process nephron development kidney development system development cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process protein dephosphorylation organonitrogen compound metabolic process dephosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process regulation of calcium ion transport regulation of localization negative regulation of transport calcium ion transport localization negative regulation of cation transmembrane transport negative regulation of calcium ion import across plasma membrane calcium ion import into cytosol monoatomic cation transport regulation of calcium ion import regulation of monoatomic ion transport import across plasma membrane inorganic ion transmembrane transport establishment of localization negative regulation of calcium ion import inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport calcium ion import across plasma membrane regulation of calcium ion import across plasma membrane negative regulation of calcium ion transmembrane transport import into cell transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport regulation of monoatomic ion transmembrane transport metal ion transport negative regulation of transmembrane transport regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of cellular process monoatomic ion transport regulation of metal ion transport calcium ion transmembrane import into cytosol regulation of transport inorganic cation import across plasma membrane negative regulation of calcium ion transport inorganic ion import across plasma membrane regulation of monoatomic cation transmembrane transport calcium ion import calcium ion transmembrane transport protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport nuclear transport organic substance transport intracellular transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport response to stress multicellular organismal response to stress trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication postsynaptic modulation of chemical synaptic transmission mitotic cell cycle process cell cycle phase transition cell cycle G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process peptidyl-serine dephosphorylation regulation of body fluid levels digestive system process regulation of system process saliva secretion positive regulation of secretion regulation of saliva secretion positive regulation of digestive system process regulation of biological quality secretion by tissue secretion regulation of digestive system process regulation of secretion body fluid secretion digestion positive regulation of transport positive regulation of saliva secretion striated muscle adaptation positive regulation of cardiac muscle hypertrophy positive regulation of cardiac muscle hypertrophy in response to stress regulation of muscle hypertrophy positive regulation of response to stimulus regulation of cardiac muscle hypertrophy in response to stress muscle adaptation cardiac muscle adaptation regulation of response to stress cardiac muscle hypertrophy positive regulation of muscle adaptation cardiac muscle hypertrophy in response to stress muscle hypertrophy regulation of muscle adaptation striated muscle hypertrophy regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy regulation of response to stimulus positive regulation of cardiac muscle adaptation positive regulation of muscle hypertrophy regulation of cardiac muscle adaptation muscle hypertrophy in response to stress regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process epithelium development epidermal cell differentiation cellular developmental process epidermis development tissue development epithelial cell differentiation skin development cell differentiation keratinocyte differentiation myotube cell development skeletal muscle fiber development skeletal muscle tissue development cell development muscle cell differentiation myotube differentiation muscle structure development skeletal muscle organ development muscle cell development muscle tissue development muscle organ development striated muscle cell differentiation transition between fast and slow fiber regulation of skeletal muscle adaptation skeletal muscle adaptation response to organic substance homeostatic process response to monosaccharide response to carbohydrate carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to organic substance response to oxygen-containing compound cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus cellular response to chemical stimulus cellular homeostasis chemical homeostasis response to glucose glucose homeostasis positive regulation of tissue remodeling positive regulation of connective tissue replacement regulation of tissue remodeling tissue remodeling connective tissue replacement regulation of connective tissue replacement positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction regulation of intracellular signal transduction regulation of calcineurin-mediated signaling positive regulation of calcineurin-NFAT signaling cascade regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling regulation of calcineurin-NFAT signaling cascade positive regulation of calcineurin-mediated signaling positive regulation of intracellular signal transduction positive regulation of signaling cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cellular component organization or biogenesis plasma membrane bounded cell projection organization dendrite morphogenesis nervous system development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development cell population proliferation regulation of cell proliferation involved in kidney morphogenesis kidney morphogenesis regulation of cell population proliferation animal organ morphogenesis regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of dendrite morphogenesis negative regulation of cellular component organization regulation of cell projection organization regulation of dendrite development negative regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization regulation of nervous system development negative regulation of neurogenesis negative regulation of nervous system development negative regulation of cell differentiation negative regulation of cell projection organization regulation of anatomical structure morphogenesis regulation of multicellular organismal development negative regulation of dendrite morphogenesis negative regulation of developmental process negative regulation of cell development regulation of plasma membrane bounded cell projection organization negative regulation of protein transport negative regulation of secretion negative regulation of hormone secretion negative regulation of secretion by cell regulation of peptide hormone secretion negative regulation of peptide hormone secretion regulation of hormone levels establishment of protein localization to extracellular region negative regulation of establishment of protein localization protein secretion regulation of protein secretion negative regulation of protein secretion regulation of hormone secretion regulation of protein localization regulation of peptide secretion hormone secretion negative regulation of cell communication protein localization to extracellular region negative regulation of peptide secretion peptide secretion secretion by cell regulation of secretion by cell amide transport signal release negative regulation of protein localization regulation of peptide transport regulation of establishment of protein localization export from cell regulation of protein transport peptide transport negative regulation of insulin secretion regulation of cellular localization regulation of insulin secretion peptide hormone secretion hormone transport insulin secretion cell adhesion positive regulation of cell adhesion regulation of cell adhesion T cell activation immune system process cell activation lymphocyte activation leukocyte activation regulation of postsynaptic membrane potential chemical synaptic transmission, postsynaptic cell surface receptor signaling pathway nervous system process excitatory postsynaptic potential regulation of membrane potential positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation positive regulation of cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process regulation of leukocyte proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation regulation of activated T cell proliferation positive regulation of leukocyte cell-cell adhesion leukocyte proliferation leukocyte cell-cell adhesion activated T cell proliferation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation positive regulation of cation transmembrane transport positive regulation of calcium ion transport positive regulation of calcium ion import positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport positive regulation of calcium ion import across plasma membrane positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport regulation of osteoblast differentiation osteoblast differentiation positive regulation of osteoblast differentiation ossification positive regulation of cell differentiation positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion wound healing response to wounding tissue regeneration skeletal muscle tissue regeneration developmental growth growth regeneration response to amine response to organonitrogen compound response to nitrogen compound response to amphetamine cellular response to nitrogen compound response to angiotensin response to peptide hormone angiotensin-activated signaling pathway cellular response to angiotensin negative regulation of G protein-coupled receptor signaling pathway cellular response to endogenous stimulus response to hormone regulation of G protein-coupled receptor signaling pathway cellular response to hormone stimulus negative regulation of response to stimulus response to endogenous stimulus cellular response to peptide hormone stimulus negative regulation of signal transduction regulation of angiotensin-activated signaling pathway cellular response to organonitrogen compound negative regulation of angiotensin-activated signaling pathway G protein-coupled receptor signaling pathway negative regulation of cellular metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process positive regulation of cellular component organization regulation of vesicle-mediated transport vesicle-mediated transport positive regulation of endocytosis endocytosis regulation of endocytosis myeloid leukocyte differentiation regulation of leukocyte differentiation positive regulation of osteoclast differentiation regulation of osteoclast differentiation positive regulation of hemopoiesis osteoclast differentiation hemopoiesis regulation of myeloid cell differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation leukocyte differentiation	intracellular anatomical structure cellular anatomical entity Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex intracellular anatomical structure cellular anatomical entity Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein serine/threonine phosphatase complex cytosol cell periphery sarcolemma plasma membrane membrane synapse cell junction glutamatergic synapse calcineurin complex intracellular protein-containing complex neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse dendrite dendritic tree extrinsic component of plasma membrane extrinsic component of membrane membrane-bounded organelle mitochondrion intracellular membrane-bounded organelle cell-cell junction anchoring junction filtration diaphragm slit diaphragm nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen Schaffer collateral - CA1 synapse
C [auth B], E [auth D]	Calcineurin subunit B isoform 1	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding protein domain specific binding enzyme regulator activity calcium-dependent protein serine/threonine phosphatase regulator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity phosphoric ester hydrolase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding protein domain specific binding enzyme regulator activity calcium-dependent protein serine/threonine phosphatase regulator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity calcium-dependent protein serine/threonine phosphatase activity catalytic activity calmodulin binding amide binding cyclosporin A binding phosphatase binding enzyme binding	calcineurin-NFAT signaling cascade cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette cellular process signal transduction calcineurin-mediated signaling calcineurin-NFAT signaling cascade cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette cellular process signal transduction calcineurin-mediated signaling developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cellular developmental process peripheral nervous system axon ensheathment peripheral nervous system development cell development nervous system development glial cell development myelination neurogenesis Schwann cell development gliogenesis axon ensheathment ensheathment of neurons glial cell differentiation cell differentiation myelination in peripheral nervous system Schwann cell differentiation positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process regulation of signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction regulation of calcineurin-mediated signaling positive regulation of calcineurin-NFAT signaling cascade regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling regulation of calcineurin-NFAT signaling cascade positive regulation of cellular process regulation of signaling positive regulation of calcineurin-mediated signaling positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling regulation of calcium ion transport regulation of localization negative regulation of biological process negative regulation of transport calcium ion transport localization negative regulation of cation transmembrane transport negative regulation of calcium ion import across plasma membrane calcium ion import into cytosol monoatomic cation transport regulation of calcium ion import regulation of monoatomic ion transport import across plasma membrane inorganic ion transmembrane transport establishment of localization negative regulation of calcium ion import inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport calcium ion import across plasma membrane regulation of calcium ion import across plasma membrane negative regulation of calcium ion transmembrane transport import into cell transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport regulation of monoatomic ion transmembrane transport metal ion transport negative regulation of transmembrane transport regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of cellular process monoatomic ion transport regulation of metal ion transport calcium ion transmembrane import into cytosol regulation of transport inorganic cation import across plasma membrane negative regulation of calcium ion transport inorganic ion import across plasma membrane regulation of monoatomic cation transmembrane transport calcium ion import calcium ion transmembrane transport protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport nuclear transport organic substance transport intracellular transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling postsynaptic modulation of chemical synaptic transmission branching morphogenesis of an epithelial tube angiogenesis tube morphogenesis epithelial tube morphogenesis blood vessel development epithelium development blood vessel morphogenesis tube development morphogenesis of an epithelium tissue development vasculature development branching involved in blood vessel morphogenesis anatomical structure morphogenesis tissue morphogenesis morphogenesis of a branching structure anatomical structure formation involved in morphogenesis morphogenesis of a branching epithelium mesenchyme development mesenchymal cell differentiation epithelial to mesenchymal transition positive regulation of cation transmembrane transport positive regulation of calcium ion transport positive regulation of calcium ion import positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport positive regulation of calcium ion import across plasma membrane positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport positive regulation of transport respiratory tube development lung epithelium development epithelial cell differentiation lung epithelial cell differentiation lung cell differentiation lung development respiratory system development positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of synaptic vesicle cycle synaptic vesicle cycle regulation of vesicle-mediated transport vesicle-mediated transport vesicle-mediated transport in synapse regulation of cellular component organization receptor internalization postsynaptic neurotransmitter receptor internalization regulation of receptor internalization cellular component organization regulation of postsynaptic neurotransmitter receptor internalization regulation of biological quality cellular component organization or biogenesis regulation of endocytosis regulation of receptor-mediated endocytosis protein-containing complex localization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis endocytosis receptor-mediated endocytosis	phosphatase complex protein-containing complex catalytic complex protein serine/threonine phosphatase complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol parallel fiber to Purkinje cell synapse synapse cell junction excitatory synapse cell periphery sarcolemma phosphatase complex protein-containing complex catalytic complex protein serine/threonine phosphatase complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol parallel fiber to Purkinje cell synapse synapse cell junction excitatory synapse cell periphery sarcolemma plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen glutamatergic synapse neuron to neuron synapse hippocampal mossy fiber to CA3 synapse calcineurin complex intracellular protein-containing complex Schaffer collateral - CA1 synapse postsynapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth A], D [auth C]	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type	Domain
B [auth A], D [auth C]	IPR029052	Metallo-dependent phosphatase-like	Homologous Superfamily
B [auth A], D [auth C]	IPR043360	PP2B	Family
B [auth A], D [auth C]	IPR041751	PP2B, metallophosphatase domain	Domain
B [auth A], D [auth C]	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase	Domain
C [auth B], E [auth D]	IPR002048	EF-hand domain	Domain
C [auth B], E [auth D]	IPR011992	EF-hand domain pair	Homologous Superfamily
C [auth B], E [auth D]	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
C [auth B], E [auth D]	IPR015757	Calcineurin B protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth A], D [auth C]	Pharos: Q08209	Wilson disease pancreatitis prostate cancer testicular disease Prevention of Liver Transplant Rejection hereditary spastic paraplegia intellectual disability large cell medulloblastoma rheumatoid arthritis lung adenocarcinoma malignant ependymoma malignant pancreatic neoplasm astrocytic tumor oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma Wilson disease pancreatitis prostate cancer testicular disease Prevention of Liver Transplant Rejection hereditary spastic paraplegia intellectual disability large cell medulloblastoma rheumatoid arthritis lung adenocarcinoma malignant ependymoma malignant pancreatic neoplasm astrocytic tumor oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma dry eye syndrome Pick disease epileptic encephalopathy, infantile or early childhood glioblastoma lung cancer malignant glioma adenoma medulloblastoma atopic eczema ovarian cancer pancreatic intraductal papillary-mucinous neoplasm breast cancer peripheral nervous system disease epilepsy pilocytic astrocytoma epileptic encephalopathy, infantile or early childhood, 1 primitive neuroectodermal tumor keratoconus subependymal giant cell astrocytoma lymphoplasmacytic lymphoma vitiligo malignant mesothelioma Alzheimer disease mucocutaneous lymph node syndrome atypical teratoid rhabdoid tumor pancreatic ductal adenocarcinoma brain injury pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia craniosynostosis peripheral neuropathy plasma cell myeloma gastroesophageal reflux disease
C [auth B], E [auth D]	Pharos: P63098	schizophrenia astrocytic tumor Gaucher disease Hypertrophy, Left Ventricular medulloblastoma osteosarcoma psoriasis subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor glioblastoma interstitial lung disease malignant ependymoma myocardial ischemia pilocytic astrocytoma rheumatoid arthritis schizophrenia astrocytic tumor Gaucher disease Hypertrophy, Left Ventricular medulloblastoma osteosarcoma psoriasis subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor glioblastoma interstitial lung disease malignant ependymoma myocardial ischemia pilocytic astrocytoma rheumatoid arthritis coronary artery disease hypertensive disorder large cell medulloblastoma malignant glioma oligodendroglioma primitive neuroectodermal tumor

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A [auth E]	NH2	RESID: AA0081 , AA0083 , AA0084 , AA0086 , AA0087 , AA0088 , AA0090 , AA0091 , AA0092 , AA0093 , AA0095 , AA0096 , AA0097 , AA0098 , AA0099 , AA0100 PSI-MOD : L-alanine amide MOD:00090 , L-asparagine amide MOD:00092 , L-aspartic acid 1-amide MOD:00093 , L-glutamine amide MOD:00095 , L-glutamic acid 1-amide MOD:00096 , glycine amide MOD:00097 , L-isoleucine amide MOD:00099 , L-leucine amide MOD:00100 , L-lysine amide MOD:00101 , L-methionine amide MOD:00102 , L-proline amide MOD:00104 , L-serine amide MOD:00105 , L-threonine amide MOD:00106 , L-tryptophan amide MOD:00107 , L-tyrosine amide MOD:00108 , L-valine amide MOD:00109

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.